KIF18A INHIBITORS

Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositi...

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Main Authors BANERJEE, Abhisek, FROHN, Michael J, LOW, Jonathan Dante, CHEN, Jian Jeffrey, MINATTI, Ana Elena, BROWN, James Alexander, BOURBEAU, Matthew Paul, LI, Kexue, JIA, Lei, PETTUS, Liping H, WALTON, Mary Catherine, MA, Vu, TAMAYO, Nuria A, LIU, Qingyian
Format Patent
LanguageEnglish
French
Published 25.06.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A. L'invention concerne des composés de formule (I) : (I), tels que définis dans la description, et des intermédiaires synthétiques de celle-ci, qui peuvent moduler la protéine KIF18A, permettant ainsi d'influencer le processus de cycle cellulaire et de prolifération cellulaire pour traiter le cancer et les maladies associées au cancer. L'invention concerne également des compositions pharmaceutiques, comprenant les composés, et des méthodes de traitement d'états pathologiques liés à l'activité de KIF18A.
Bibliography:Application Number: WO2019US68169