METHOD FOR ESTIMATING THE EFFECTIVENESS OF A TREATMENT BY AN ANTI-TNF ALPHA AGENT IN A PATIENT SUFFERING FROM RHEUMATOID ARTHRITIS AND HAVING AN INADEQUATE RESPONSE TO AT LEAST ONE BIOTHERAPY
The present invention relates to a method for estimating the effectiveness of a treatment by an anti-TNFα agent in a patient suffering from rheumatoid arthritis and having an inadequate response to at least one prior biotherapy, consisting in analyzing a biological sample of said patient for the exp...
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Format | Patent |
Language | English French |
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25.06.2020
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Abstract | The present invention relates to a method for estimating the effectiveness of a treatment by an anti-TNFα agent in a patient suffering from rheumatoid arthritis and having an inadequate response to at least one prior biotherapy, consisting in analyzing a biological sample of said patient for the expression of a set of biomarkers, the results of which allowing to determine whether said agent is a treatment which will engender a beneficial response for said patient. The present invention also relates to a system for estimating the effectiveness of said treatment in said patient, comprising means for measuring or receiving data concerning the level of expression of said biomarkers and means for processing said data, which are configured to estimate the effectiveness of said treatment in said patient.
La présente invention concerne un procédé d'estimation de l'efficacité de traitement par un agent anti-TNFα chez un patient atteint de polyarthrite rhumatoïde et qui a été en réponse inadéquante à au moins une biothérapie antérieure, consistant à analyser un échantillon biologique dudit patient pour l'expression d'un ensemble de biomarqueurs, dont les résultats permettent de déterminer si ledit agent est un traitement qui engendrera une réponse bénéfique pour ledit patient. La présente invention concerne également un système d'estimation de l'efficacité dudit traitement chez ledit patient comprenant des moyens de mesure ou de réception des données, du niveau d'expression desdits biomarqueurs et des moyens de traitement de ces données configurés pour estimer ladite efficacité dudit traitement chez ledit patient. |
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AbstractList | The present invention relates to a method for estimating the effectiveness of a treatment by an anti-TNFα agent in a patient suffering from rheumatoid arthritis and having an inadequate response to at least one prior biotherapy, consisting in analyzing a biological sample of said patient for the expression of a set of biomarkers, the results of which allowing to determine whether said agent is a treatment which will engender a beneficial response for said patient. The present invention also relates to a system for estimating the effectiveness of said treatment in said patient, comprising means for measuring or receiving data concerning the level of expression of said biomarkers and means for processing said data, which are configured to estimate the effectiveness of said treatment in said patient.
La présente invention concerne un procédé d'estimation de l'efficacité de traitement par un agent anti-TNFα chez un patient atteint de polyarthrite rhumatoïde et qui a été en réponse inadéquante à au moins une biothérapie antérieure, consistant à analyser un échantillon biologique dudit patient pour l'expression d'un ensemble de biomarqueurs, dont les résultats permettent de déterminer si ledit agent est un traitement qui engendrera une réponse bénéfique pour ledit patient. La présente invention concerne également un système d'estimation de l'efficacité dudit traitement chez ledit patient comprenant des moyens de mesure ou de réception des données, du niveau d'expression desdits biomarqueurs et des moyens de traitement de ces données configurés pour estimer ladite efficacité dudit traitement chez ledit patient. |
Author | COURTIER, Anaïs GUIGUE, Lisa GOTTENBERG, Jacques-Eric BAILLET, Athan GAUDIN, Philippe NGUYEN, Chuong |
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DocumentTitleAlternate | PROCEDE D'ESTIMATION DE L'EFFICACITE DE TRAITEMENT PAR UN AGENT ANTI-TNF ALPHA CHEZ UN PATIENT ATTEINT DE POLYARTHRITE RHUMATOÏDE ET EN REPONSE INADEQUATE A AU MOINS UNE BIOTHERAPIE |
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Snippet | The present invention relates to a method for estimating the effectiveness of a treatment by an anti-TNFα agent in a patient suffering from rheumatoid... |
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Title | METHOD FOR ESTIMATING THE EFFECTIVENESS OF A TREATMENT BY AN ANTI-TNF ALPHA AGENT IN A PATIENT SUFFERING FROM RHEUMATOID ARTHRITIS AND HAVING AN INADEQUATE RESPONSE TO AT LEAST ONE BIOTHERAPY |
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