PYRROLO[2,3-D]PYRIMIDINE TOSYLATE SALT, CRYSTALLINE FORM THEREOF AND MANUFACTURING PROCESS AND INTERMEDIATES THERETO

• Main Authors: GIRARD, Kevin Paul, GOEKEN, Gregory Scott, CRITCHER, Douglas James, DANIELS, David Sydney Bernard, SAMAS, Brian Matthew, ROSE, Peter Robert, TAO, Yong
• Format: Patent
• Language: English; French
• Published: 30.04.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention discloses a novel p-toluenesulfonic acid salt and a crystalline polymorphic Form 1 of said salt of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one, pharmaceutical composition containing the same, as well as preparations and uses thereof. The present invention also discloses a novel phosphoric acid salt of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one, pharma-ceutical composition containing the same, as well as preparations and uses thereof. La présente invention concerne un nouveau sel d'acide p-toluènesulfonique et une forme 1 polymorphe cristalline dudit sel de 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-méthylpipéridin-1-yl)prop-2-èn-1-one, une composition pharmaceutique le contenant, ainsi que des préparations et des utilisations associées. La présente invention concerne également un nouveau sel d'acide phosphorique de 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-méthylpipéridin-1-yl)prop-2-èn-1-one, une composition pharmaceutique le contenant, ainsi que des préparations et des utilisations associées.