NOVEL NADH-DEPENDENT ENZYME MUTANTS TO CONVERT ACETONE INTO ISOPROPANOL

The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified al...

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Main Authors GOUVEA, Iuri Estrada, QUEIROZ, Veronica Leite, PARIZZI, Lucas Pedersen, NASCIMENTO, Alessandro Silva, GUIDO, Rafael Victorio Carvalho, OKAMOTO, Debora Noma, POLIKARPOV, Igor
Format Patent
LanguageEnglish
French
Published 10.10.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides. La présente invention concerne des processus et des systèmes biologiques pour la production d'isopropanol et/ou d'acétone faisant appel à des alcools déshydrogénases modifiées qui présentent une activité accrue avec le NADH en tant que cofacteur. L'invention concerne en outre des polynucléotides et des polypeptides des alcools déshydrogénases modifiées, et des cellules hôtes contenant les polynucléotides et exprimant les polypeptides.
Bibliography:Application Number: WO2019US26363