OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO
Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid recept...
Saved in:
Main Authors | , , , , , , , , , , , , |
---|---|
Format | Patent |
Language | English French |
Published |
10.10.2019
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.
La présente invention concerne des composés représentés par la formule (I) : ou un isomère, racémate, hydrate, solvate, isotope ou sel pharmaceutiquement acceptables de ceux-ci, dans la formule A, B, L, R3, R4, R5, R6, R8, m et n sont tels que définis dans la description. Les composés selon l'invention sont des modulateurs du récepteur opioïde, en particulier le récepteur mu-opioïde (MOR) et/ou le récepteur kappa-opioïde (KOR), et/ou le récepteur delta-opioïde (DOR). L'invention concerne également des produits contenant de tels composés, ainsi que des procédés se rapportant à leur utilisation et leur préparation. |
---|---|
AbstractList | Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.
La présente invention concerne des composés représentés par la formule (I) : ou un isomère, racémate, hydrate, solvate, isotope ou sel pharmaceutiquement acceptables de ceux-ci, dans la formule A, B, L, R3, R4, R5, R6, R8, m et n sont tels que définis dans la description. Les composés selon l'invention sont des modulateurs du récepteur opioïde, en particulier le récepteur mu-opioïde (MOR) et/ou le récepteur kappa-opioïde (KOR), et/ou le récepteur delta-opioïde (DOR). L'invention concerne également des produits contenant de tels composés, ainsi que des procédés se rapportant à leur utilisation et leur préparation. |
Author | SADLOWSKI, Corinne LI, Yihong MEDINA, Julio Cesar SEIDL, Frederick MCGEE, Larry WEI, Zhi-Liang SPERANDIO, David NERURKAR, Alok NGUYEN, Thomas WANG, Xiaodong DING, Pingyu BHATT, Ulhas DUQUETTE, Jason |
Author_xml | – fullname: SEIDL, Frederick – fullname: BHATT, Ulhas – fullname: NGUYEN, Thomas – fullname: SPERANDIO, David – fullname: WEI, Zhi-Liang – fullname: DING, Pingyu – fullname: NERURKAR, Alok – fullname: DUQUETTE, Jason – fullname: SADLOWSKI, Corinne – fullname: MEDINA, Julio Cesar – fullname: LI, Yihong – fullname: WANG, Xiaodong – fullname: MCGEE, Larry |
BookMark | eNrjYmDJy89L5WRw9g_w9Pd0UQhydXYNCPEPUvD1dwn1cQSyghUc_VwUAoKAfOcQCMfXNcTD3yUYqBiowtVFIcTDNcg1xJ-HgTUtMac4lRdKczMou7mGOHvophbkx6cWFyQmp-allsSH-xsZGFoaWpqaGZs4GhoTpwoAFCEuZA |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | MODULATEURS DU RÉCEPTEUR OPIOÏDE, PRODUITS ET PROCÉDÉS ASSOCIÉS |
ExternalDocumentID | WO2019195634A1 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_WO2019195634A13 |
IEDL.DBID | EVB |
IngestDate | Fri Sep 20 10:13:51 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English French |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_WO2019195634A13 |
Notes | Application Number: WO2019US25910 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191010&DB=EPODOC&CC=WO&NR=2019195634A1 |
ParticipantIDs | epo_espacenet_WO2019195634A1 |
PublicationCentury | 2000 |
PublicationDate | 20191010 |
PublicationDateYYYYMMDD | 2019-10-10 |
PublicationDate_xml | – month: 10 year: 2019 text: 20191010 day: 10 |
PublicationDecade | 2010 |
PublicationYear | 2019 |
RelatedCompanies | EPIODYNE, INC |
RelatedCompanies_xml | – name: EPIODYNE, INC |
Score | 3.2354164 |
Snippet | Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof,... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191010&DB=EPODOC&locale=&CC=WO&NR=2019195634A1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1dS8MwFL2MKeqbTsWPKQGlb8XZdq19GNIlKZ3YpXSZ7m2YroIg3XAV_743Xad72ltuLoQkcG7uyccJwK3lzh4spTqm7793TSfzXVN1vZmpMtfOMcVHDqH3O-KhG42dp0l30oDP9VuYSif0pxJHRERliPeyiteL_00sVt2tXN6pD6yaP4ayx4yaHSP5QH5hsH6PJ4IJalCKvM0YpisfcgHbCZAr7ehEWivt85e-fpey2FxUwkPYTbC9ojyCRl60YJ-u_15rwV5cH3ljsUbf8hioSAZiwEjKKU-kSEks2Pg5wNKIBENGkhRtKldGzGUk2IjoPzEwOhEZ8ZRLcQI3IZc0MrE307_BT1_FZtftU2gW8yI_A5Ij9hwPpzTTGviWrxBM6g3THa3o5ubeObS3tXSx3X0JB9rUUfq-04Zm-fWdX-HyW6rratZ-AVZugRg |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfZ3PT8IwFMdfCBrxpqjxB2oTzW6LCGNzB2JG22UoW5dRlBuxYyYmZhCZ8d_3dYBy4tb2JU3b5PvaT3-8Aty27OlDS6mm6brvHdNKXdtUHWdqqtRuZ7jER4bQ-x1hZAcj62ncGVfgc_0WpowT-lMGR0RFpaj3ovTX8_9NLFberVzcqQ8smj36ssuMFR0jfCBfGKzX5bFgghqUIrcZUbK0IQu0LQ9ZacdBKCxh6aWn36XMNycV_wB2Y6wvLw6hkuV1qNH132t12AtXR96YXKlvcQRUxH3RZyThlMdSJCQUbDTwMDUkXsRInGCeymUm5DIQbEj0nxjonYgMeMKlOIYbn0samNiayV_nJ69is-ntE6jmszw7BZKh9iwHhzTVMfBbrkIxqTdc7uiIbnbmnEFjW03n283XUAtkOJgM-tHzBexrk_bY980GVIuv7-wSp-JCXZUj-AuE3IQC |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=OPIOID+RECEPTOR+MODULATORS+AND+PRODUCTS+AND+METHODS+RELATED+THERETO&rft.inventor=SEIDL%2C+Frederick&rft.inventor=BHATT%2C+Ulhas&rft.inventor=NGUYEN%2C+Thomas&rft.inventor=SPERANDIO%2C+David&rft.inventor=WEI%2C+Zhi-Liang&rft.inventor=DING%2C+Pingyu&rft.inventor=NERURKAR%2C+Alok&rft.inventor=DUQUETTE%2C+Jason&rft.inventor=SADLOWSKI%2C+Corinne&rft.inventor=MEDINA%2C+Julio+Cesar&rft.inventor=LI%2C+Yihong&rft.inventor=WANG%2C+Xiaodong&rft.inventor=MCGEE%2C+Larry&rft.date=2019-10-10&rft.externalDBID=A1&rft.externalDocID=WO2019195634A1 |