A TARGET CELL-DEPENDENT T CELL ENGAGING AND ACTIVATION ASYMMETRIC HETERODIMERIC Fc-ScFv FUSION ANTIBODY FORMAT FOR CANCER THERAPY
An asymmetric heterodimeric antibody includes a knob structure formed in a CH3 domain of a first heavy chain; a hole structure formed in a CH3 domain of a second heavy chain, wherein the hole structure is configured to accommodate the knob structure so that a heterodimeric antibody is formed; and a...
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Format | Patent |
Language | English French |
Published |
27.12.2018
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Abstract | An asymmetric heterodimeric antibody includes a knob structure formed in a CH3 domain of a first heavy chain; a hole structure formed in a CH3 domain of a second heavy chain, wherein the hole structure is configured to accommodate the knob structure so that a heterodimeric antibody is formed; and a T-cell targeting domain fused to the CH3 domain of the first heavy chain or the second heavy chain, wherein the T-cell targeting domain binds specifically to an antigen on the T-cell. The T-cell targeting domain is a ScFv or Fab derived from an anti-CD3 antibody. The asymmetric heterodimeric antibody may have L234A and L235A mutations or L235A and G237A such that its effector binding is compromised.
La présente invention concerne un anticorps hétérodimère asymétrique qui comprend une structure de bouton formée dans un domaine CH3 d'une première chaîne lourde ; une structure de trou formée dans un domaine CH3 d'une seconde chaîne lourde, la structure de trou étant conçue pour recevoir la structure de bouton de sorte qu'un anticorps hétérodimérique est formé ; et un domaine de ciblage de lymphocytes T fusionné au domaine CH3 de la première chaîne lourde ou de la seconde chaîne lourde, le domaine de ciblage de lymphocytes T se liant spécifiquement à un antigène sur le lymphocyte T. Le domaine de ciblage de lymphocytes T est un ScFv ou Fab dérivé d'un anticorps anti-CD3. L'anticorps hétérodimère asymétrique peut présenter des mutations L234A et L235A ou L235A et G237A de sorte que sa liaison effectrice est compromise. |
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AbstractList | An asymmetric heterodimeric antibody includes a knob structure formed in a CH3 domain of a first heavy chain; a hole structure formed in a CH3 domain of a second heavy chain, wherein the hole structure is configured to accommodate the knob structure so that a heterodimeric antibody is formed; and a T-cell targeting domain fused to the CH3 domain of the first heavy chain or the second heavy chain, wherein the T-cell targeting domain binds specifically to an antigen on the T-cell. The T-cell targeting domain is a ScFv or Fab derived from an anti-CD3 antibody. The asymmetric heterodimeric antibody may have L234A and L235A mutations or L235A and G237A such that its effector binding is compromised.
La présente invention concerne un anticorps hétérodimère asymétrique qui comprend une structure de bouton formée dans un domaine CH3 d'une première chaîne lourde ; une structure de trou formée dans un domaine CH3 d'une seconde chaîne lourde, la structure de trou étant conçue pour recevoir la structure de bouton de sorte qu'un anticorps hétérodimérique est formé ; et un domaine de ciblage de lymphocytes T fusionné au domaine CH3 de la première chaîne lourde ou de la seconde chaîne lourde, le domaine de ciblage de lymphocytes T se liant spécifiquement à un antigène sur le lymphocyte T. Le domaine de ciblage de lymphocytes T est un ScFv ou Fab dérivé d'un anticorps anti-CD3. L'anticorps hétérodimère asymétrique peut présenter des mutations L234A et L235A ou L235A et G237A de sorte que sa liaison effectrice est compromise. |
Author | YU, Jei-Hwa WU, Chia-Cheng LIN, Tzu-Yin HUANG, Chao-Yang CHIEN, Chen-Li CHEN, Yu-Jung |
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DocumentTitleAlternate | FORMAT D'ANTICORPS HYBRIDE FC-SCFV HÉTÉRODIMÈRE ASYMÉTRIQUE D'ACTIVATION ET IMPLIQUANT DES LYMPHOCYTES T DÉPENDANT DE CELLULES CIBLES POUR LA CANCÉROTHÉRAPIE |
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Snippet | An asymmetric heterodimeric antibody includes a knob structure formed in a CH3 domain of a first heavy chain; a hole structure formed in a CH3 domain of a... |
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Title | A TARGET CELL-DEPENDENT T CELL ENGAGING AND ACTIVATION ASYMMETRIC HETERODIMERIC Fc-ScFv FUSION ANTIBODY FORMAT FOR CANCER THERAPY |
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