BLOOD VESSEL MODEL

The present disclosure provides a blood vessel model including: a pair of channel members, mutually opposing each other, each of which includes an opposing face in which a respective microchannel is formed; and a porous membrane that includes plural through-holes penetrating in a thickness direction...

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Main Authors KAKINUMA, Chihaya, ITO, Koju, HIKIMOTO, Daichi, MIMA, Shinji, SUEHIRO, Takafumi, NEVILLE, Craig, SUNDBACK, Cathryn
Format Patent
LanguageEnglish
French
Published 13.12.2018
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Summary:The present disclosure provides a blood vessel model including: a pair of channel members, mutually opposing each other, each of which includes an opposing face in which a respective microchannel is formed; and a porous membrane that includes plural through-holes penetrating in a thickness direction, that is disposed between the opposing faces of the pair of channel members, and that partitions between the microchannels, wherein the porous membrane is provided with a vascular endothelial cell layer so as to cover one face facing one of the microchannels, an average opening diameter of the through-holes is from 1 μιη to 20 μm, and an opening coverage ratio of the through-holes is from 30% to 70%. La présente invention concerne un modèle de vaisseau sanguin comprenant : une paire d'éléments canaux, mutuellement opposés, chacun comprenant une face opposée dans laquelle est formé un microcanal respectif ; et une membrane poreuse qui comprend plusieurs orifices traversants pénétrant dans une direction d'épaisseur, qui est disposée entre les faces opposées de la paire d'éléments canaux, et qui sépare les microcanaux, la membrane poreuse étant dotée d'une couche de cellules endothéliales vasculaires de manière à recouvrir une face faisant face à l'un des microcanaux, un diamètre d'ouverture moyen des orifices traversants étant de 1 µm à 20 µm, et un rapport de couverture d'ouverture des orifices traversants étant de 30 % à 70 %.
Bibliography:Application Number: WO2018US36364