PYRAZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES

The invention relates to triazole compounds of formula (I) or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions a...

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Bibliographic Details
Main Authors FRANTZ, James, COLLIER, Philip, SYKEN, Joshua, GU, Wenxin, KRAUSS, Raul, POROLA, Emanuele, DAVIES, Robert, GRILLOT, Anne-Laure, KOLPAK, Adrianne, RYU, Elizabeth, DOYLE, Elizabeth, MAGAVI, Sanjay, GOLDMAN, Brian
Format Patent
LanguageEnglish
French
Published 14.06.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to triazole compounds of formula (I) or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis. L'invention concerne des composés de triazole de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci, utiles en tant que modulateurs de maladies démyélinisantes. L'invention concerne également des compositions pharmaceutiquement acceptables comprenant les composés de l'invention, des procédés d'utilisation des compositions et des kits associés dans le traitement de diverses maladies démyélinisantes et neurodégénératives, notamment la sclérose en plaques.
Bibliography:Application Number: WO2017US64627