INHALABLE POWDER COMPOSITION COMPRISING IL-13 ANTIBODY
An inhalable powder composition comprises a) an antagonistic antibody which binds human IL-13, b) leucine and c) trehalose. The antibody may comprise a heavy chain, wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:3 and a light chain, wherein the variable doma...
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Format | Patent |
Language | English French |
Published |
03.05.2018
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Abstract | An inhalable powder composition comprises a) an antagonistic antibody which binds human IL-13, b) leucine and c) trehalose. The antibody may comprise a heavy chain, wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:3 and a light chain, wherein the variable domain of the light chain comprises the sequence given in SEQ ID NO:1. Also described is the use of such compositions in the treatment of asthma, as well as inhalers containing such compositions.
La présente invention concerne une composition de poudre inhalable comprenant : a) un anticorps antagoniste qui se lie à l'IL -13 humaine, b) de la leucine, et c) du tréhalose. L'anticorps peut comprendre une chaîne lourde, le domaine variable de la chaîne lourde comprenant la séquence donnée dans SEQ ID NO : 3 et une chaîne légère, le domaine variable de la chaîne légère comprenant la séquence donnée dans SEQ ID NO : 1. L'invention concerne également l'utilisation de telles compositions dans le traitement de l'asthme, ainsi que des inhalateurs contenant de telles compositions. |
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AbstractList | An inhalable powder composition comprises a) an antagonistic antibody which binds human IL-13, b) leucine and c) trehalose. The antibody may comprise a heavy chain, wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:3 and a light chain, wherein the variable domain of the light chain comprises the sequence given in SEQ ID NO:1. Also described is the use of such compositions in the treatment of asthma, as well as inhalers containing such compositions.
La présente invention concerne une composition de poudre inhalable comprenant : a) un anticorps antagoniste qui se lie à l'IL -13 humaine, b) de la leucine, et c) du tréhalose. L'anticorps peut comprendre une chaîne lourde, le domaine variable de la chaîne lourde comprenant la séquence donnée dans SEQ ID NO : 3 et une chaîne légère, le domaine variable de la chaîne légère comprenant la séquence donnée dans SEQ ID NO : 1. L'invention concerne également l'utilisation de telles compositions dans le traitement de l'asthme, ainsi que des inhalateurs contenant de telles compositions. |
Author | PALFRAMAN, Roger MAIN, Mark Jonathan MORGAN, Frazer Giles KIRKE, David |
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DocumentTitleAlternate | COMPOSITION DE POUDRE INHALABLE COMPRENANT UN ANTICORPS IL -13 |
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RelatedCompanies | UCB BIOPHARMA SPRL VECTURA LIMITED |
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Snippet | An inhalable powder composition comprises a) an antagonistic antibody which binds human IL-13, b) leucine and c) trehalose. The antibody may comprise a heavy... |
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SubjectTerms | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
Title | INHALABLE POWDER COMPOSITION COMPRISING IL-13 ANTIBODY |
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