AN IMPROVED PROCESS FOR THE PREPARATION OF DEXMETHYL PHENIDATE HYDROCHLORIDE
Disclosed herein a process for the preparation of highly pure dexmethylphenidate hydrochloride (Formula-I) which comprises the steps of neutralization of dl- threomethylphenidate hydrochloride to dl-threo methylphenidate; subsequent resolution of dl-threo methylphenidate using amino acid or its deri...
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| Format | Patent |
| Language | English French |
| Published |
25.01.2018
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| Subjects | |
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| Abstract | Disclosed herein a process for the preparation of highly pure dexmethylphenidate hydrochloride (Formula-I) which comprises the steps of neutralization of dl- threomethylphenidate hydrochloride to dl-threo methylphenidate; subsequent resolution of dl-threo methylphenidate using amino acid or its derivatives as chiral resolution agent to yield dexmethylphenidate salt; hydrolysis of the salt and further conversion of dexmethylphenidate into its hydrochloride salt.
L'invention concerne un procédé de préparation de l'hydrochlorure de dexméthylphénidate hautement pur (formule-I) qui comprend les étapes de neutralisation de l'hydrochlorure de dl-threométhylphénidate en dl-thréométhylphénidate; la résolution ultérieure du dl-thréométhylphénidate à l'aide d'un acide aminé ou de ses dérivés en tant qu'agent de résolution chiral pour produire le sel de dexméthylphénidate; l'hydrolyse du sel et la conversion supplémentaire du dexméthylphénidate en son sel d'hydrochlorure. |
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| AbstractList | Disclosed herein a process for the preparation of highly pure dexmethylphenidate hydrochloride (Formula-I) which comprises the steps of neutralization of dl- threomethylphenidate hydrochloride to dl-threo methylphenidate; subsequent resolution of dl-threo methylphenidate using amino acid or its derivatives as chiral resolution agent to yield dexmethylphenidate salt; hydrolysis of the salt and further conversion of dexmethylphenidate into its hydrochloride salt.
L'invention concerne un procédé de préparation de l'hydrochlorure de dexméthylphénidate hautement pur (formule-I) qui comprend les étapes de neutralisation de l'hydrochlorure de dl-threométhylphénidate en dl-thréométhylphénidate; la résolution ultérieure du dl-thréométhylphénidate à l'aide d'un acide aminé ou de ses dérivés en tant qu'agent de résolution chiral pour produire le sel de dexméthylphénidate; l'hydrolyse du sel et la conversion supplémentaire du dexméthylphénidate en son sel d'hydrochlorure. |
| Author | MINHAS, Harpreet Singh MINHAS, Gurpreet Singh KADAM, Vijay Trimbak SARANAPU, Nareesh CHAVAN, Santosh Uttamrao |
| Author_xml | – fullname: SARANAPU, Nareesh – fullname: MINHAS, Harpreet Singh – fullname: KADAM, Vijay Trimbak – fullname: MINHAS, Gurpreet Singh – fullname: CHAVAN, Santosh Uttamrao |
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| DocumentTitleAlternate | PROCÉDÉ DE PRÉPARATION AMÉLIORÉ DE L'HYDROCHLORURE DE DEXMÉTHYLE PHÉNIDATE |
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| Notes | Application Number: WO2017IN50293 |
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| RelatedCompanies | HARMAN FINOCHEM LIMITED |
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| Snippet | Disclosed herein a process for the preparation of highly pure dexmethylphenidate hydrochloride (Formula-I) which comprises the steps of neutralization of dl-... |
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| Title | AN IMPROVED PROCESS FOR THE PREPARATION OF DEXMETHYL PHENIDATE HYDROCHLORIDE |
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