2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS
The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same. La présente invention concerne des inhibiteurs de SHP2 et leur utilisation dans le traitement de maladies. La présente invention con...
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| Main Authors | , , , , , , , , |
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| Format | Patent |
| Language | English French |
| Published |
18.01.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
La présente invention concerne des inhibiteurs de SHP2 et leur utilisation dans le traitement de maladies. La présente invention concerne en outre des compositions pharmaceutiques comprenant ceux-ci. |
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| AbstractList | The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
La présente invention concerne des inhibiteurs de SHP2 et leur utilisation dans le traitement de maladies. La présente invention concerne en outre des compositions pharmaceutiques comprenant ceux-ci. |
| Author | BUCKL, Andreas KOLTUN, Elena S AAY, Naing JOGALEKAR, Ash SEMKO, Christopher GILL, Adrian MELLEM, Kevin KISS, Gert WON, Walter |
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| DocumentTitleAlternate | 3-MÉTHYLPYRAZINES 2,5-DISUBSTITUÉES ET 3-MÉTHYL PYRAZINES 2,5,6-TRISUBSTITUÉS EN TANT QU'INHIBITEURS ALLOSTÉRIQUES DE SHP2 |
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| RelatedCompanies | JOGALEKAR, Ash REVOLUTION MEDICINES, INC WON, Walter |
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| Snippet | The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising... |
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| Title | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS |
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