HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA

• Main Authors: JOHNSON, Patrick Stephen, MAANSSON, Kristoffer, JESSIMAN, Alan Stuart, SØRENSEN, Morten Dahl
• Format: Patent
• Language: English; French
• Published: 18.01.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is -CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl- (C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or -ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds. La présente invention concerne des composés selon la formule générale (I) où X représente N ou CH; R1 est -CN, (C1-C6alkyle, (C3-C7 cycloalkyle, (3-7 membre)hétérocycloalkyle, (5-6 membre)hétéroaryle, (C3-C7) cycloalkyle (C1-C4 alkyle, (3-7 membre) hétérocycloalkyle-(C1-C4 alkyle ou (5-6 membre) hétéroaryle-(C1-C4 alkyle; R2 est un halogène, un cyano, (C1-C4 alkyle ou (C3-C7 cycloalkyle; R3 est un halogène, un cyano, (C1-C4 alkyle, (C1-C4 haloalkyle ou (C3-C7) cycloalkyle; R4 est (C1-C4 alkyle ou (C1-C4 haloalkyle; R5 est (C1-C6 alkyle, (C3-C7 cycloalkyle, (C1-C6 alkyle-(C3-C7) cycloalkyle, (C3-C7 cycloalkyle-(C1-C6) alkyle, (3-7 membre) hétérocycloalkyle, phényle, (5-6 membre) hétéroaryle ou ORa. L'invention concerne également lesdits composés pour l'utilisation en thérapie, des compositions pharmaceutiques comprenant ces composés et des produits intermédiaires pour la préparation desdits composés.