SUBSTITUTED 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3(2H)-ONES AND 2,5,6,7-TETRAHYDRO-3H-PYRROLO[2,1-C][1,2,4]TRIAZOL-3-ONES, AND USE THEREOF

• Main Authors: NEUBAUER, Thomas, TIMMERMANN, Andreas, LINDNER, Niels, GERICKE, Kersten Matthias, MEIER, Heinrich, ZUBOV, Dmitry, BIBER, Nicole, SCHULZ, Alexander, MIYATAKE ONDOZABAL, Hideki, MOORE, Steven, KÖLLING, Florian, MOOSMAYER, Dieter, BADOCK, Volker, BROCKSCHNEIDER, Damian, LUSTIG, Klemens, TERJUNG, Carsten, SCHÄFER, Martina, MEDING, Jörg
• Format: Patent
• Language: English; French; German
• Published: 16.11.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Die vorliegende Anmeldung betrifft neue substituierte 5,6,7,8-Tetrahydro[1,2,4]triazolo[4,3- a]pyridin-3(2H)-one und 2,5,6,7-tetrahydro-3H-pyrrolo[2,1 -c][1,2,4]triazol-3-one, Verfahren zu ihrer Herstellung, ihre Verwendung allein oder in Kombinationen zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere zur Behandlung und/oder Prophylaxe von inflammatorischen Lungen-Erkrankungen The present application relates to new substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to methods for the synthesis thereof, the use thereof alone or in combination for the treatment and/or prophylaxis of diseases, and the use thereof for manufacturing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of inflammatory pulmonary diseases. La présente invention concerne de nouvelles 5,6,7,8-tétrahydro[1,2,4]triazolo[4,3- a]pyridin-3(2H)-ones et 2,5,6,7-tétrahydro-3H-pyrrolo[2,1 -c][1,2,4]triazol-3-ones substituées, leurs procédés de production, leur utilisation seuls ou en association pour le traitement et/ou la prophylaxie de maladies, ainsi que leur utilisation pour la production de médicaments servant au traitement et/ou à la prophylaxie de maladies, notamment au traitement et/ou à la prophylaxie de maladies pulmonaires.