AN AMORPHOUS FORM OF SOFOSBUVIR, A METHOD OF ITS PREPARATION AND ITS STABILIZATION

• Main Authors: KREJCIK, Lukas, OBADALOVA, Iva
• Format: Patent
• Language: English; French
• Published: 09.11.2017
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; SUGARS

The invention relates to a preparation method of an amorphous form of sofosbuvir of formula I, (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-l(2H)-yl)-4- fluoro-3-hydroxy-4-memyltetrahydrofuran-2-yl)methoxy)-(phenoxy)phosphorylamino)- propanoate, in particular aging of the a...