FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
A series of fused pentacyclic imidazole derivatives, being potent modulators of f benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disord...
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| Main Authors | , |
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| Format | Patent |
| Language | English French |
| Published |
05.10.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | A series of fused pentacyclic imidazole derivatives, being potent modulators of f benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 5,7,8,15-tetrahydro-6H-8,15- methanobenzimidazo[1,2-b][2,5]benzodiazocin-6-one derivatives and analogs thereof.
L'invention concerne une série de dérivés d'imidazole pentacycliques condensés qui sont de puissants modulateurs de l'activité du TNFα humain, et sont ainsi efficaces dans le traitement et/ou la prévention de diverses affections humaines, dont les troubles auto-immuns et inflammatoires ; les troubles neurologiques et neurodégénératifs ; la douleur et les troubles nociceptifs ; les troubles cardiovasculaires ; les troubles métaboliques ; les troubles oculaires ; et les troubles oncologiques. En particulier, la présente invention concerne les dérivés de 5,7,8,15-tétrahydro-6H-8,15-méthanobenzimidazo[1,2-b][2,5]benzodiazocin-6-one et des analogues de ceux-ci. |
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| AbstractList | A series of fused pentacyclic imidazole derivatives, being potent modulators of f benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 5,7,8,15-tetrahydro-6H-8,15- methanobenzimidazo[1,2-b][2,5]benzodiazocin-6-one derivatives and analogs thereof.
L'invention concerne une série de dérivés d'imidazole pentacycliques condensés qui sont de puissants modulateurs de l'activité du TNFα humain, et sont ainsi efficaces dans le traitement et/ou la prévention de diverses affections humaines, dont les troubles auto-immuns et inflammatoires ; les troubles neurologiques et neurodégénératifs ; la douleur et les troubles nociceptifs ; les troubles cardiovasculaires ; les troubles métaboliques ; les troubles oculaires ; et les troubles oncologiques. En particulier, la présente invention concerne les dérivés de 5,7,8,15-tétrahydro-6H-8,15-méthanobenzimidazo[1,2-b][2,5]benzodiazocin-6-one et des analogues de ceux-ci. |
| Author | KEYAERTS, Jean HEER, Jag Paul |
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| DocumentTitleAlternate | DÉRIVÉS D'IMIDAZOLE PENTACYCLIQUES CONDENSÉS UTILISÉS EN TANT QUE MODULATEURS DE L'ACTIVITÉ DU TNF |
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| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| Title | FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY |
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