METHODS OF INHIBITING PATHOLOGICAL ANGIOGENESIS WITH DOPPEL-TARGETING MOLECULES

• Main Authors: JANG, Ye Ji, BYUN, Young Ro, TASLIM, Ahmed Al-Hilal, KIM, In San, KIM, Sang Yoon
• Format: Patent
• Language: English; French
• Published: 22.02.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; VINEGAR; WINE

Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described. L'invention concerne des molécules ciblant la protéine Doppel utiles pour inhiber une angiogenèse pathologique et traiter des maladies et des affections associées à une angiogenèse pathologique, telles que les tumeurs, les cancers, l'athérosclérose, la tuberculose, l'asthme, l'hypertension artérielle pulmonaire (HTAP), les néoplasmes et les troubles associés aux néoplasmes, tumeurs et pour détecter l'expression de la protéine Doppel chez un sujet. L'invention concerne également des compositions et des procédés associés.