N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS

The disclosed subject matter provides N- hydroxylsulfonamide derivative compounds of formulae (I), (II) or (III) as drawn below, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, t...

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Main Authors COURTNEY, Stephen, Martin, FROST, Lisa, Marie, BROOKFIELD, Frederick Arthur, TOSCANO, John P, KALISH, Vincent Jacob
Format Patent
LanguageEnglish
French
Published 27.04.2017
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The disclosed subject matter provides N- hydroxylsulfonamide derivative compounds of formulae (I), (II) or (III) as drawn below, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure. La présente invention concerne des composés dérivés N-hydroxylsulfonamide de formule (I), (II) ou (III) tels que représentés ci-dessous, des compositions pharmaceutiques comprenant de tels composés, des kits comprenant de tels composés, et des procédés d'utilisation de tels composés ou de telles compositions pharmaceutiques. L'invention concerne en particulier des procédés d'utilisation de tels composés ou de telles compositions pharmaceutiques pour traiter une insuffisance cardiaque.
Bibliography:Application Number: WO2016US57478