POLYMERIC NANOPARTICLES WITH DEC-205 LIGAND AND CO-ENCAPSULATING AN ANTIGEN SUBJECT TO AN AUTOIMMUNE RESPONSE AND A GLUCOCORTICOID RECEPTOR AGONIST

The present invention provides a nanoparticle comprising a polymeric matrix and a covalently-bound surface-orientated targeting ligand for DEC-205, said polymeric matrix encapsulating an antigen which is the subject of an undesirable immune response and a glucocorticoid receptor agonist. The nanopar...

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Bibliographic Details
Main Authors PAK, Roger Hochoon, EDMONDS, Jason Nash, LOOK, Michael Wai-Haung, BENSON, Micah James, DARVARI, Ramin
Format Patent
LanguageEnglish
French
Published 16.02.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a nanoparticle comprising a polymeric matrix and a covalently-bound surface-orientated targeting ligand for DEC-205, said polymeric matrix encapsulating an antigen which is the subject of an undesirable immune response and a glucocorticoid receptor agonist. The nanoparticles of the invention can be used to treat autoimmune diseases such as haemophilia A and multiple sclerosis. La présente invention concerne une nanoparticule comprenant une matrice polymère et un ligand de ciblage orienté vers la surface, lié de façon covalente pour DEC -205, ladite matrice polymère encapsulant un antigène qui est le sujet d'une réponse immunitaire indésirable et un agoniste de récepteur de glucocorticoïde. Les nanoparticules de l'invention peuvent être utilisées pour traiter des maladies auto-immunes telles que l'hémophilie A et la sclérose en plaques.
Bibliography:Application Number: WO2016IB54769