FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS

• Main Authors: KIM, MOONSOO, CHOI, SOONGYU, JUNG, MYUNG, EUN, LEE, KI, NAM, KIM, HYE, KYOUNG, LEE, CHAEWOON, JEONG, HANKYUL, CHOI, HYANG, YOON, CHEOLHWAN, LEE, GILNAM, KIM, JAY, HAK, KIM, HYUN, JUNG, SEO, JEONGBEOB, LEE, MINWOO, LEE, JAE, IL, KIM, MISOON
• Format: Patent
• Language: English; French
• Published: 04.08.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The disclosure provides novel chemical compounds represented by Formula (I) or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative...