PHARMACEUTICAL COMPOSITION CONTAINING PORTULACA GRANDIFLORA HOOK. EXTRACT OR FRACTION THEREOF AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING NEUROINFLAMMATION OR NEURO-DEGENERATIVE DISEASES

• Main Authors: KWON, SEUNG HWAN, JANG, CHOON GON, CHOI, SANG HO, LEE, JOONG KU
• Format: Patent
• Language: English; French; Korean
• Published: 03.03.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pharmaceutical composition and a food composition containing Portulaca grandiflora Hook. extract or a fraction thereof as an active ingredient for preventing, treating or ameliorating neuroinflammation or neuro-degenerative diseases. The Portulaca grandiflora Hook. extract or a fraction thereof according to the present invention is derived from a natural product which has been in use as a natural medicinal ingredient, and as such, has no side effects and inhibits expression of NO, PGE2, iNOS and/or COX-2 genes or protein, which are factors associated with inflammation, and is additionally superbly effective for increasing and improving memory and the ability to learn, and thus can be beneficially used to prevent or treat neuroinflammation or neuro-degenerative diseases. La présente invention concerne une composition pharmaceutique et une composition alimentaire contenant un extrait de Portulaca grandiflora Hook. ou une fraction de celui-ci comme principe actif pour prévenir, traiter ou améliorer une inflammation des nerfs ou des maladies neurodégénératives. L'extrait de Portulaca grandiflora Hook. ou une fraction de celui-ci, selon la présente invention, est dérivé d'un produit naturel qui a été utilisé comme ingrédient en médecine naturelle et, en tant que tel, n'a pas d'effets secondaires, et qui inhibe l'expression de protéine ou de gènes NO, PGE2, iNOS et/ou COX-2, qui sont des facteurs associés à une inflammation, et qui est également très efficace pour augmenter et améliorer la mémoire et la capacité d'apprentissage, et qui peut donc être avantageusement utilisé pour prévenir ou traiter une inflammation des nerfs ou des maladies neurodégénératives. 본 발명은 채송화(Portulaca grandiflora Hook.) 추출물 또는 이의 분획물을 유효성분으로 포함하는 신경염증 또는 퇴행성 뇌신경 질환의 예방, 치료 또는 개선용 약학적 조성물 및 식품 조성물에 관한 것이다. 본 발명의 채송화 추출물 또는 이의 분획물은 천연약재로 사용되어온 천연물에서 유래되어 부작용이 없으면서도, 염증관련 인자인 NO, PGE2, iNOS 및/또는 COX-2 유전자 또는 단백질의 발현을 억제할 뿐만 아니라, 학습 또는 기억력 증진 및 개선 효과가 우수하므로 신경염증 또는 퇴행성 뇌신경 질환의 예방 또는 치료에 있어 유용하게 사용될 수 있다.