METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS
Provided herein, in some embodiments, are methods of using certain cereblon- associated proteins, such as Aiolos, Ikaros, interferon (IFN), and IFN pathway proteins, casein kinase 1, alpha 1 (CSNK1A1), and ZFP9, as biomarkers for use in predicting and monitoring clinical sensitivity and therapeutic...
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Format | Patent |
Language | English French |
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12.11.2015
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Abstract | Provided herein, in some embodiments, are methods of using certain cereblon- associated proteins, such as Aiolos, Ikaros, interferon (IFN), and IFN pathway proteins, casein kinase 1, alpha 1 (CSNK1A1), and ZFP9, as biomarkers for use in predicting and monitoring clinical sensitivity and therapeutic response to certain compounds in patients having various diseases and disorders, such as cancers (e.g., diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM), myelodysplasia syndromes (MDS) and acute myeloid leukemia (AML)) and IFN-associated disorders. Also provided herein, in certain embodiments, are methods of determining the efficacy of an immunomodulatory compound.
L'invention concerne, dans certains modes de réalisation, des méthodes d'utilisation de certaines protéines associées au céréblon, par exemple Aiolos, Ikaros, l'interféron (IFN) et les protéines des voies de l'IFN, la caséine kinase 1, l'alpha-1 (CSNK1A1) et ZFP9, comme biomarqueurs à utiliser pour prédire et surveiller la sensibilité clinique et la réponse thérapeutique à certains composés chez les patients présentant différentes pathologies et affections, par exemple le cancer [lymphome diffus à grandes cellules B (LDGCB), myélome multiple (MM), syndromes myélodysplasiques (SMD) et leucémie myéloïde aiguë (LMA)] et les affections associées à l'IFN. Dans certains modes de réalisation, l'invention concerne des méthodes de détermination de l'efficacité d'un composé immunomodulateur. |
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AbstractList | Provided herein, in some embodiments, are methods of using certain cereblon- associated proteins, such as Aiolos, Ikaros, interferon (IFN), and IFN pathway proteins, casein kinase 1, alpha 1 (CSNK1A1), and ZFP9, as biomarkers for use in predicting and monitoring clinical sensitivity and therapeutic response to certain compounds in patients having various diseases and disorders, such as cancers (e.g., diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM), myelodysplasia syndromes (MDS) and acute myeloid leukemia (AML)) and IFN-associated disorders. Also provided herein, in certain embodiments, are methods of determining the efficacy of an immunomodulatory compound.
L'invention concerne, dans certains modes de réalisation, des méthodes d'utilisation de certaines protéines associées au céréblon, par exemple Aiolos, Ikaros, l'interféron (IFN) et les protéines des voies de l'IFN, la caséine kinase 1, l'alpha-1 (CSNK1A1) et ZFP9, comme biomarqueurs à utiliser pour prédire et surveiller la sensibilité clinique et la réponse thérapeutique à certains composés chez les patients présentant différentes pathologies et affections, par exemple le cancer [lymphome diffus à grandes cellules B (LDGCB), myélome multiple (MM), syndromes myélodysplasiques (SMD) et leucémie myéloïde aiguë (LMA)] et les affections associées à l'IFN. Dans certains modes de réalisation, l'invention concerne des méthodes de détermination de l'efficacité d'un composé immunomodulateur. |
Author | HAGNER, PATRICK REN, YAN KLIPPEL, ANKE WANG, MARIA, YINGLIN COUTO, SUZANA, STURLINI HOLLENBACH, PAUL HAVENS, COURTNEY, G GANDHI, ANITA TROTTER, MATTHEW WILLIAM, BURNELL BREIDER, MIKE CHOPRA, RAJESH MACBETH, KYLE |
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DocumentTitleAlternate | MÉTHODES DE DÉTERMINATION DE L'EFFICACITÉ PHARMACOLOGIQUE DU TRAITEMENT DU LYMPHOME DIFFUS À GRANDES CELLULES B, DU MYÉLOME MULTIPLE ET DES CANCERS MYÉLOÏDES |
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Snippet | Provided herein, in some embodiments, are methods of using certain cereblon- associated proteins, such as Aiolos, Ikaros, interferon (IFN), and IFN pathway... |
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Title | METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS |
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