COMPLEXES OF CYCLOSPORINE A AND ITS DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
The present invention relates to pharmaceutically accepted complex formulae comprising complexes of Cyclosporine A or derivatives thereof and complexation agents and pharmaceutically accepted excipients, process for the preparation thereof and pharmaceutical compositions containing them. The complex...
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| Format | Patent |
| Language | English French |
| Published |
21.05.2015
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| Online Access | Get full text |
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| Abstract | The present invention relates to pharmaceutically accepted complex formulae comprising complexes of Cyclosporine A or derivatives thereof and complexation agents and pharmaceutically accepted excipients, process for the preparation thereof and pharmaceutical compositions containing them. The complex formulae of the present invention have improved physicochemical properties and decreased variability and food effect and are useful in the treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis and severe psoriasis.
La présente invention concerne des formules de complexes pharmaceutiquement acceptables comprenant des complexes de cyclosporine A ou des dérivés de celle-ci et des agents de complexation et des excipients pharmaceutiquement acceptables, leur procédé de préparation et des compositions pharmaceutiques contenant ceux-ci. Les formules de complexe de la présente invention ont des propriétés physico-chimiques améliorées, une variabilité réduite et un effet alimentaire et sont utiles dans le traitement d'un rejet de greffe (rein, foie et cœur), de la polyarthrite rhumatoïde et du psoriasis sévère. |
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| AbstractList | The present invention relates to pharmaceutically accepted complex formulae comprising complexes of Cyclosporine A or derivatives thereof and complexation agents and pharmaceutically accepted excipients, process for the preparation thereof and pharmaceutical compositions containing them. The complex formulae of the present invention have improved physicochemical properties and decreased variability and food effect and are useful in the treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis and severe psoriasis.
La présente invention concerne des formules de complexes pharmaceutiquement acceptables comprenant des complexes de cyclosporine A ou des dérivés de celle-ci et des agents de complexation et des excipients pharmaceutiquement acceptables, leur procédé de préparation et des compositions pharmaceutiques contenant ceux-ci. Les formules de complexe de la présente invention ont des propriétés physico-chimiques améliorées, une variabilité réduite et un effet alimentaire et sont utiles dans le traitement d'un rejet de greffe (rein, foie et cœur), de la polyarthrite rhumatoïde et du psoriasis sévère. |
| Author | ÖTVÖS, ZSOLT MOLNÁR, LÁSZLÓ FILIPCSEI, GENOVÉVA ANGI, ERZSÉBET, RÉKA FENYVESI, ZSÓFIA HELTOVICS, GÁBOR KÁRPÁTI, RICHARD, BALÁZS GLAVINAS, HRISTOS FERENCZI, KATALIN SOLYMOSI, TAMÁS |
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| Snippet | The present invention relates to pharmaceutically accepted complex formulae comprising complexes of Cyclosporine A or derivatives thereof and complexation... |
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| Title | COMPLEXES OF CYCLOSPORINE A AND ITS DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
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