METHODS AND PRODUCTS FOR THE DIAGNOSIS AND PROGNOSIS OF OVARIAN TUMOR MALIGNANCY
The present invention relates to methods and products for the diagnosis and prognosis of ovarian tumor malignancy based on proCOL11A1 protein which is expressed in malignant ovarian tumors but not in non-tumoral ovarian tissue or in situor benign or borderline ovarian tumors. proCOL11A1-specific ant...
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Format | Patent |
Language | English French |
Published |
09.04.2015
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Abstract | The present invention relates to methods and products for the diagnosis and prognosis of ovarian tumor malignancy based on proCOL11A1 protein which is expressed in malignant ovarian tumors but not in non-tumoral ovarian tissue or in situor benign or borderline ovarian tumors. proCOL11A1-specific antibodies can be used for high sensitivity and specificity diagnosis of ovarian cancer as well as for differentiating malignant ovarian tumors from benign or in situ tumors, and for the prognosis of ovarian tumor malignancy and for predicting borderline tumor malignancy. The invention has application in in vitromethods for the diagnosis and prognosis of ovarian tumor malignancy.
La présente invention concerne des procédés et des produits pour le diagnostic et le pronostic d'une malignité tumorale ovarienne basés sur la protéine proCOL11A1 qui est exprimée dans les tumeurs ovariennes malignes mais non dans le tissu ovarien non tumoral ou des tumeurs ovariennes in situ ou bénignes ou à la limité de la malignité. Des anticorps spécifiques de proCOL11A1 peuvent être utilisés pour un diagnostic de sensibilité et de spécificité élevées du cancer de l'ovaire ainsi que pour différencier des tumeurs ovarienne malignes de tumeurs bénignes ou in situ, et pour le pronostic d'une malignité tumorale ovarienne et pour prévoir une malignité tumoral limite. L'invention a des applications dans des procédés in vitro de diagnostic et de pronostic d'une malignité tumorale ovarienne. |
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AbstractList | The present invention relates to methods and products for the diagnosis and prognosis of ovarian tumor malignancy based on proCOL11A1 protein which is expressed in malignant ovarian tumors but not in non-tumoral ovarian tissue or in situor benign or borderline ovarian tumors. proCOL11A1-specific antibodies can be used for high sensitivity and specificity diagnosis of ovarian cancer as well as for differentiating malignant ovarian tumors from benign or in situ tumors, and for the prognosis of ovarian tumor malignancy and for predicting borderline tumor malignancy. The invention has application in in vitromethods for the diagnosis and prognosis of ovarian tumor malignancy.
La présente invention concerne des procédés et des produits pour le diagnostic et le pronostic d'une malignité tumorale ovarienne basés sur la protéine proCOL11A1 qui est exprimée dans les tumeurs ovariennes malignes mais non dans le tissu ovarien non tumoral ou des tumeurs ovariennes in situ ou bénignes ou à la limité de la malignité. Des anticorps spécifiques de proCOL11A1 peuvent être utilisés pour un diagnostic de sensibilité et de spécificité élevées du cancer de l'ovaire ainsi que pour différencier des tumeurs ovarienne malignes de tumeurs bénignes ou in situ, et pour le pronostic d'une malignité tumorale ovarienne et pour prévoir une malignité tumoral limite. L'invention a des applications dans des procédés in vitro de diagnostic et de pronostic d'une malignité tumorale ovarienne. |
Author | DOMINGUEZ HORMAETXE, SAIOA SIMON BUELA, LAUREANO |
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DocumentTitleAlternate | PROCÉDÉS ET PRODUITS POUR LE DIAGNOSTIC ET LE PRONOSTIC D'UNE MALIGNITÉ TUMORALE OVARIENNE |
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Snippet | The present invention relates to methods and products for the diagnosis and prognosis of ovarian tumor malignancy based on proCOL11A1 protein which is... |
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Title | METHODS AND PRODUCTS FOR THE DIAGNOSIS AND PROGNOSIS OF OVARIAN TUMOR MALIGNANCY |
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