ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF
The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compo...
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Format | Patent |
Language | English French |
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15.01.2015
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Abstract | The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond.
La présente invention concerne des analogues de rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-méthylpipéridin-4-yl)-4H-chromén-4-one) de formule A et des sels pharmaceutiquement acceptables de ceux-ci. De plus, l'invention concerne des compositions pharmaceutiquement acceptables comprenant au moins un tel composé, et des procédés d'utilisation des composés pour le traitement ou la prévention de divers troubles prolifératifs tels que le mélanome, la leucémie, le cancer du sein et le cancer de la prostate, etc. [insérer la formule A ici] dans laquelle, n=0 ou 1, la ligne en pointillés indique la double liaison. |
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AbstractList | The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond.
La présente invention concerne des analogues de rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-méthylpipéridin-4-yl)-4H-chromén-4-one) de formule A et des sels pharmaceutiquement acceptables de ceux-ci. De plus, l'invention concerne des compositions pharmaceutiquement acceptables comprenant au moins un tel composé, et des procédés d'utilisation des composés pour le traitement ou la prévention de divers troubles prolifératifs tels que le mélanome, la leucémie, le cancer du sein et le cancer de la prostate, etc. [insérer la formule A ici] dans laquelle, n=0 ou 1, la ligne en pointillés indique la double liaison. |
Author | MONDHE, DILIP MANIKRAO MEENA, SAMDARSHI BHARATE, SANDIP BIBISHAN GURU, SANTOSH KUMAR JAIN, SHREYANS KUMAR BHARATE, SONALI SANDIP VISHWAKARMA, RAM ASREY BEHL, AKANKSHA KUMAR, SURESH JOSHI, PRASHANT PATHANIA, ANUP SINGH MINTOO, MUBASHIR JAVED BHUSHAN, SHASHI |
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DocumentTitleAlternate | ANALOGUES DE ROHITUKINE COMME INHIBITEURS DES KINASES DÉPENDANTES DES CYCLINES ET SON PROCÉDÉ DE PRÉPARATION |
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Snippet | The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and... |
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Title | ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF |
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