ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF

• Main Authors: KUMAR, SURESH, MONDHE, DILIP MANIKRAO, GURU, SANTOSH KUMAR, PATHANIA, ANUP SINGH, JOSHI, PRASHANT, BHARATE, SANDIP BIBISHAN, VISHWAKARMA, RAM ASREY, MINTOO, MUBASHIR JAVED, BEHL, AKANKSHA, JAIN, SHREYANS KUMAR, BHUSHAN, SHASHI, MEENA, SAMDARSHI, BHARATE, SONALI SANDIP
• Format: Patent
• Language: English; French
• Published: 15.01.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond. La présente invention concerne des analogues de rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-méthylpipéridin-4-yl)-4H-chromén-4-one) de formule A et des sels pharmaceutiquement acceptables de ceux-ci. De plus, l'invention concerne des compositions pharmaceutiquement acceptables comprenant au moins un tel composé, et des procédés d'utilisation des composés pour le traitement ou la prévention de divers troubles prolifératifs tels que le mélanome, la leucémie, le cancer du sein et le cancer de la prostate, etc. [insérer la formule A ici] dans laquelle, n=0 ou 1, la ligne en pointillés indique la double liaison.