SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS
The invention provides a chemical entity of Formula (I), wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and and their use in a wide range of methods, including metabolic and reaction kinetic studies, de...
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Format | Patent |
Language | English French |
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02.10.2014
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Abstract | The invention provides a chemical entity of Formula (I), wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive or motor impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non- human animal training protocols, and treating treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.
L'invention porte sur une entité chimique de formule (I), dans laquelle R1, R2, R3, Y et n ont l'une quelconque des valeurs décrites dans la description, et sur des compositions comprenant de telles entités chimiques ; sur des procédés de fabrication de celles-ci ; et sur leur utilisation dans un large éventail de procédés, notamment des études métaboliques et de cinétique de réaction, des techniques de détection et d'imagerie et des traitements radioactifs, et de thérapies, notamment l'inhibition de MAO et de MAO-B sélectivement, l'accroissement de la plasticité neuronale, le traitement de troubles neurologiques, la fourniture d'une neuroprotection, le traitement d'un déficit cognitif ou moteur associé à un trouble du SNC, l'amélioration de l'efficacité d'un entraînement cognitif et moteur, la fourniture d'une neuro-récupération et neuro-réhabilitation, l'accroissement de l'efficacité de protocoles d'entraînement d'animaux non humains et le traitement de troubles périphériques (notamment l'obésité, le diabète et les troubles cardiométaboliques) et de leurs comorbidités associées. |
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AbstractList | The invention provides a chemical entity of Formula (I), wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive or motor impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non- human animal training protocols, and treating treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.
L'invention porte sur une entité chimique de formule (I), dans laquelle R1, R2, R3, Y et n ont l'une quelconque des valeurs décrites dans la description, et sur des compositions comprenant de telles entités chimiques ; sur des procédés de fabrication de celles-ci ; et sur leur utilisation dans un large éventail de procédés, notamment des études métaboliques et de cinétique de réaction, des techniques de détection et d'imagerie et des traitements radioactifs, et de thérapies, notamment l'inhibition de MAO et de MAO-B sélectivement, l'accroissement de la plasticité neuronale, le traitement de troubles neurologiques, la fourniture d'une neuroprotection, le traitement d'un déficit cognitif ou moteur associé à un trouble du SNC, l'amélioration de l'efficacité d'un entraînement cognitif et moteur, la fourniture d'une neuro-récupération et neuro-réhabilitation, l'accroissement de l'efficacité de protocoles d'entraînement d'animaux non humains et le traitement de troubles périphériques (notamment l'obésité, le diabète et les troubles cardiométaboliques) et de leurs comorbidités associées. |
Author | KAPLAN, ALAN FREESTONE, GRAEME GUPTA, VARSHA BASINGER, JILLIAN SENGUPTA, DIPANJAN PRATT, BENJAMIN BREITENBUCHER, JAMES MAK, CHIING SANTORA, VINCENT VALDEZ, LINO |
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DocumentTitleAlternate | COMPOSÉS DE NAPHTYRIDINE ET DE QUINOLÉINE SUBSTITUÉS UTILISÉS COMME INHIBITEURS DE MONOAMINE OXYDASES (MAO) |
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Snippet | The invention provides a chemical entity of Formula (I), wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such... |
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SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS |
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