DDX3 AS A BIOMARKER FOR CANCER AND METHODS RELATED THERETO
The invention encompasses methods for treating or preventing diseases and disorders associated abnormal cell growth, for example, treating or preventing cancer or tumor growth, by administering to a subject in need thereof a composition comprising a therapeutically or prophylactically effective amou...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French |
| Published |
25.09.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The invention encompasses methods for treating or preventing diseases and disorders associated abnormal cell growth, for example, treating or preventing cancer or tumor growth, by administering to a subject in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound that downregulates DDX3, for example a fused diimidazodiazepine ring compound or a pharmaceutically acceptable salt thereof. The invention also encompasses the use of DDX3 as a biomarker for diagnostic and treatment purposes, for example, to identify a hyperproliferative disorder susceptible to treatment by down regulation of DDX3. |
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| AbstractList | The invention encompasses methods for treating or preventing diseases and disorders associated abnormal cell growth, for example, treating or preventing cancer or tumor growth, by administering to a subject in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound that downregulates DDX3, for example a fused diimidazodiazepine ring compound or a pharmaceutically acceptable salt thereof. The invention also encompasses the use of DDX3 as a biomarker for diagnostic and treatment purposes, for example, to identify a hyperproliferative disorder susceptible to treatment by down regulation of DDX3. |
| Author | VAN DIEST, PAUL, JOANNES RAMAN, VENU BOL, GUUS, MARTINUS |
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| Discipline | Medicine Chemistry Sciences |
| DocumentTitleAlternate | DDX3 SERVANT DE BIOMARQUEUR POUR LE CANCER ET MÉTHODES ASSOCIÉES |
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| Notes | Application Number: WO2013US71021 |
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| PublicationYear | 2014 |
| RelatedCompanies | THE JOHNS HOPKINS UNIVERSITY |
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| Snippet | The invention encompasses methods for treating or preventing diseases and disorders associated abnormal cell growth, for example, treating or preventing cancer... |
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| Title | DDX3 AS A BIOMARKER FOR CANCER AND METHODS RELATED THERETO |
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