PHENYLPYRAZOLE DERIVATIVES AS POTENT ROCK1 AND ROCK2 INHIBITORS

The present invention provides compounds of Formula (I): (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprisin...

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Bibliographic Details
Main Authors QUAN, MIMI L, HU, ZILUN
Format Patent
LanguageEnglish
French
Published 04.09.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of Formula (I): (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same. La présente invention concerne des composés représentés par la formule (I) : (I) ou leurs stéréoisomères, tautomères, ou sels pharmaceutiquement acceptables, dans laquelle toutes les variables sont telles que définies dans la présente invention. Ces composés sont des inhibiteurs sélectifs de ROCK. La présente invention concerne aussi des compositions pharmaceutiques comprenant ces composés et des procédés pour le traitement de troubles cardiovasculaires, des muscles lisses, oncologiques, neuropathiques, auto-immuns, fibreus et/ou inflammatoires à l'aide de ces compositions.
Bibliography:Application Number: WO2014US19242