VACCINE FOR HPV INFECTION AND/OR HEPATITIS B CONTAINING HPV/HBS CHIMERIC PROTEIN AS ACTIVE INGREDIENT
A chimeric protein made from a HPV-L2 peptide and an HBs protein, said HPV-L2 peptide being one of the following: (1) a peptide comprising the 20 amino acids of the core sequence region; (2) a peptide comprising part of the core sequence region, namely the six amino acids glycine, glycine, leucine,...
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Format | Patent |
Language | English French Japanese |
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03.07.2014
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Abstract | A chimeric protein made from a HPV-L2 peptide and an HBs protein, said HPV-L2 peptide being one of the following: (1) a peptide comprising the 20 amino acids of the core sequence region; (2) a peptide comprising part of the core sequence region, namely the six amino acids glycine, glycine, leucine, glycine, isoleucine, and glycine; or (3) a peptide comprising up to 70 amino acids, obtained by adding amino acids derived from the HPV-L2 protein to the N-terminus and/or the C-terminus of the core sequence region. Also, a vaccine for HPV infection and/or hepatitis B, said vaccine containing the aforementioned chimeric protein as an active ingredient. A vaccine containing this chimeric protein exhibits increased expression levels in the host, resulting in improved immunizing capacity (early antibody inducement), and has a wide spectrum, being effective on a large number of HPV types.
Cette invention concerne une protéine chimérique constituée d'un peptide HPV-L2 et d'une protéine HBs, ledit peptide HPV-L2 étant l'un des suivants : (1) un peptide comprenant les 20 acides aminés de la région de la séquence cœur ; (2) un peptide comprenant une partie de la région de la séquence cœur, à savoir les six acides aminés glycine, glycine, leucine, glycine, isoleucine, et glycine ; ou (3) un peptide comprenant jusqu'à 70 acides aminés, obtenu par ajout d'acides aminés dérivés de la protéine HPV-L2 à l'extrémité N-terminale et/ou à l'extrémité C-terminale de la région de la séquence cœur. En plus, cette invention concerne un vaccin contre l'infection par le HPV et/ou l'hépatite B, ledit vaccin contenant la protéine chimérique précitée à titre de principe actif. Un vaccin contenant cette protéine chimérique manifeste des niveaux d'expression accrus chez l'hôte, avec pour résultat une capacité d'immunisation améliorée (induction d'anticorps précoce), a un large spectre, et est efficace sur un grand nombre de types de HPV. |
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AbstractList | A chimeric protein made from a HPV-L2 peptide and an HBs protein, said HPV-L2 peptide being one of the following: (1) a peptide comprising the 20 amino acids of the core sequence region; (2) a peptide comprising part of the core sequence region, namely the six amino acids glycine, glycine, leucine, glycine, isoleucine, and glycine; or (3) a peptide comprising up to 70 amino acids, obtained by adding amino acids derived from the HPV-L2 protein to the N-terminus and/or the C-terminus of the core sequence region. Also, a vaccine for HPV infection and/or hepatitis B, said vaccine containing the aforementioned chimeric protein as an active ingredient. A vaccine containing this chimeric protein exhibits increased expression levels in the host, resulting in improved immunizing capacity (early antibody inducement), and has a wide spectrum, being effective on a large number of HPV types.
Cette invention concerne une protéine chimérique constituée d'un peptide HPV-L2 et d'une protéine HBs, ledit peptide HPV-L2 étant l'un des suivants : (1) un peptide comprenant les 20 acides aminés de la région de la séquence cœur ; (2) un peptide comprenant une partie de la région de la séquence cœur, à savoir les six acides aminés glycine, glycine, leucine, glycine, isoleucine, et glycine ; ou (3) un peptide comprenant jusqu'à 70 acides aminés, obtenu par ajout d'acides aminés dérivés de la protéine HPV-L2 à l'extrémité N-terminale et/ou à l'extrémité C-terminale de la région de la séquence cœur. En plus, cette invention concerne un vaccin contre l'infection par le HPV et/ou l'hépatite B, ledit vaccin contenant la protéine chimérique précitée à titre de principe actif. Un vaccin contenant cette protéine chimérique manifeste des niveaux d'expression accrus chez l'hôte, avec pour résultat une capacité d'immunisation améliorée (induction d'anticorps précoce), a un large spectre, et est efficace sur un grand nombre de types de HPV. |
Author | SAKAGUCHI, MASASHI KANDA, TADAHITO IMAMURA, TAKASHI MORI, SEIICHIRO YONEMURA, HIROSHI |
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DocumentTitleAlternate | VACCIN CONTRE L'INFECTION PAR LE HPV ET/OU L'HÉPATITE B CONTENANT UNE PROTÉINE HPV/HBS CHIMÉRIQUE À TITRE DE PRINCIPE ACTIF |
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Snippet | A chimeric protein made from a HPV-L2 peptide and an HBs protein, said HPV-L2 peptide being one of the following: (1) a peptide comprising the 20 amino acids... |
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Title | VACCINE FOR HPV INFECTION AND/OR HEPATITIS B CONTAINING HPV/HBS CHIMERIC PROTEIN AS ACTIVE INGREDIENT |
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