LEVOTHYROXINE FORMULATION WITH ACACIA

A pharmaceutical composition comprising thyroxine, acacia, and an antioxidant selected from propyl gallate, butylated hydroxyanisol, and butylated hydroxytoluene is disclosed. The pharmaceutical composition has an improved shelf life. In one embodiment, the composition additionally comprises sucrose...

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Bibliographic Details
Main Authors NALLAMOTHU, RAMAKRISHNA, KIRSCH, JOHN, POLAT, BARIS, E
Format Patent
LanguageEnglish
French
Published 26.06.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A pharmaceutical composition comprising thyroxine, acacia, and an antioxidant selected from propyl gallate, butylated hydroxyanisol, and butylated hydroxytoluene is disclosed. The pharmaceutical composition has an improved shelf life. In one embodiment, the composition additionally comprises sucrose, microcrystalline cellulose, and mannitol. The pharmaceutical composition may be used for treating thyroid disorders by orally administering the composition to a patient in need thereof. La présente invention concerne une composition pharmaceutique comprenant de la thyroxine, de la gomme arabique, et un antioxydant choisi parmi le gallate de propyle, l'hydroxyanisol butylé et de l'hydroxytoluène butylé. La composition pharmaceutique a une durée de conservation améliorée. Dans un mode de réalisation, la composition comprend en outre du saccharose, de la cellulose microcristalline et du mannitol. La composition pharmaceutique peut être utilisée pour traiter des troubles de la thyroïde par administration par voie orale de la composition à un patient nécessitant cela.
Bibliography:Application Number: WO2012US71184