HIGHLY LOADED AMORPHOUS EFAVIRENZ COMPOSITION AND PROCESS FOR PREPARING THE SAME
A stable and high loading ternary solid dispersion composition comprising (a) about 50% wt. to about 90% wt. of amorphous Efavirenz; (b) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone (PVP), a first polymer; (c) about 1 % wt. to about 30% wt. of a water-soluble second polymer; and (d) optio...
Saved in:
Main Authors | , , , , |
---|---|
Format | Patent |
Language | English French |
Published |
17.07.2014
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | A stable and high loading ternary solid dispersion composition comprising (a) about 50% wt. to about 90% wt. of amorphous Efavirenz; (b) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone (PVP), a first polymer; (c) about 1 % wt. to about 30% wt. of a water-soluble second polymer; and (d) optionally about 0.1% wt. to about 50% wt. of at least one pharmaceutically acceptable excipient. Also disclosed is a high loading ternary composition comprising (a) a solid dispersion composition comprising (i) about 50% wt. to about 90% wt. of amorphous Efavirenz; (ii) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone, a first polymer; (b) about 1 % wt. to about 30% wt. of a water-soluble second polymer blended with the solid dispersion composition and (c) optionally about 0.1 % wt. to about 50% wt. of at least one pharmaceutically acceptable excipient. Additionally disclosed is a method for preparing solid dosage forms comprising (i) amorphous Efavirenz and (ii) polyvinyl pyrrolidone (PVP), a first polymer; (iii) a water-soluble second polymer; and (iv) optionally, at least one pharmaceutical excipient.
L'invention concerne une composition en dispersion solide ternaire stable et à haute charge comprenant (a) environ 50 % pds à environ 90 % pds d'éfavirenz amorphe ; (b) environ 10 % pds à environ 50 % pds de polyvinylpyrrolidone (PVP), un premier polymère ; (c) environ 1 % pds à environ 30 % pds d'un second polymère hydrosoluble ; et (d) éventuellement, environ 0,1 % pds à environ 50 % pds d'au moins un excipient pharmaceutiquement acceptable. L'invention concerne également une composition ternaire à haute charge comprenant (a) une composition en dispersion solide comprenant (i) environ 50 % pds à environ 90 % pds d'éfavirenz amorphe ; (ii) environ 10 % pds à environ 50 % pds de polyvinylpyrrolidone, un premier polymère ; (b) environ 1 % pds à environ 30 % pds d'un second polymère hydrosoluble mélangé avec la composition en dispersion solide et (c) éventuellement, environ 0,1 % pds à environ 50 % pds d'au moins un excipient pharmaceutiquement acceptable. L'invention concerne en outre un procédé pour préparer des formes posologiques solides comprenant (i) de l'éfavirenz amorphe et (ii) de la polyvinylpyrrolidone (PVP), un premier polymère ; (iii) un second polymère hydrosoluble ; et (iv) éventuellement, au moins un excipient pharmaceutique. |
---|---|
AbstractList | A stable and high loading ternary solid dispersion composition comprising (a) about 50% wt. to about 90% wt. of amorphous Efavirenz; (b) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone (PVP), a first polymer; (c) about 1 % wt. to about 30% wt. of a water-soluble second polymer; and (d) optionally about 0.1% wt. to about 50% wt. of at least one pharmaceutically acceptable excipient. Also disclosed is a high loading ternary composition comprising (a) a solid dispersion composition comprising (i) about 50% wt. to about 90% wt. of amorphous Efavirenz; (ii) about 10% wt. to about 50% wt. of polyvinyl pyrrolidone, a first polymer; (b) about 1 % wt. to about 30% wt. of a water-soluble second polymer blended with the solid dispersion composition and (c) optionally about 0.1 % wt. to about 50% wt. of at least one pharmaceutically acceptable excipient. Additionally disclosed is a method for preparing solid dosage forms comprising (i) amorphous Efavirenz and (ii) polyvinyl pyrrolidone (PVP), a first polymer; (iii) a water-soluble second polymer; and (iv) optionally, at least one pharmaceutical excipient.
L'invention concerne une composition en dispersion solide ternaire stable et à haute charge comprenant (a) environ 50 % pds à environ 90 % pds d'éfavirenz amorphe ; (b) environ 10 % pds à environ 50 % pds de polyvinylpyrrolidone (PVP), un premier polymère ; (c) environ 1 % pds à environ 30 % pds d'un second polymère hydrosoluble ; et (d) éventuellement, environ 0,1 % pds à environ 50 % pds d'au moins un excipient pharmaceutiquement acceptable. L'invention concerne également une composition ternaire à haute charge comprenant (a) une composition en dispersion solide comprenant (i) environ 50 % pds à environ 90 % pds d'éfavirenz amorphe ; (ii) environ 10 % pds à environ 50 % pds de polyvinylpyrrolidone, un premier polymère ; (b) environ 1 % pds à environ 30 % pds d'un second polymère hydrosoluble mélangé avec la composition en dispersion solide et (c) éventuellement, environ 0,1 % pds à environ 50 % pds d'au moins un excipient pharmaceutiquement acceptable. L'invention concerne en outre un procédé pour préparer des formes posologiques solides comprenant (i) de l'éfavirenz amorphe et (ii) de la polyvinylpyrrolidone (PVP), un premier polymère ; (iii) un second polymère hydrosoluble ; et (iv) éventuellement, au moins un excipient pharmaceutique. |
Author | RAHMAN, MOHAMMED, ABDUL DURIG, THOMAS BI, YUNXIA LESTER, JAMES, DAVID BULL, RANDY |
Author_xml | – fullname: LESTER, JAMES, DAVID – fullname: DURIG, THOMAS – fullname: RAHMAN, MOHAMMED, ABDUL – fullname: BULL, RANDY – fullname: BI, YUNXIA |
BookMark | eNqNyr0KwjAUQOEMOvj3DhechdZW6HppbptAmxuSqOhSisRJ2kJ9f3TwAZzON5y1WAzjEFfCKl2r5gYNoyQJ2LKzis8eqMKLdmTuUHJr2eug2QAaCdZxSd5Dxe5rsui0qSEoAo8tbcXy2b_muPt1I_YVhVId4jR2cZ76Rxziu7vyMUnzpEhPRYpZ9t_1AXtcMdc |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | COMPOSITION D'ÉFAVIRENZ AMORPHE À HAUTE CHARGE ET PROCÉDÉ POUR LA PRÉPARER |
ExternalDocumentID | WO2014081581A3 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_WO2014081581A33 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 11:26:22 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English French |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_WO2014081581A33 |
Notes | Application Number: WO2013US69030 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140717&DB=EPODOC&CC=WO&NR=2014081581A3 |
ParticipantIDs | epo_espacenet_WO2014081581A3 |
PublicationCentury | 2000 |
PublicationDate | 20140717 |
PublicationDateYYYYMMDD | 2014-07-17 |
PublicationDate_xml | – month: 07 year: 2014 text: 20140717 day: 17 |
PublicationDecade | 2010 |
PublicationYear | 2014 |
RelatedCompanies | ISP INVESTMENTS INC |
RelatedCompanies_xml | – name: ISP INVESTMENTS INC |
Score | 2.949706 |
Snippet | A stable and high loading ternary solid dispersion composition comprising (a) about 50% wt. to about 90% wt. of amorphous Efavirenz; (b) about 10% wt. to about... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDEDFOR SHAPING OR JOINING OF PLASTICS TRANSPORTING WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL |
Title | HIGHLY LOADED AMORPHOUS EFAVIRENZ COMPOSITION AND PROCESS FOR PREPARING THE SAME |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140717&DB=EPODOC&locale=&CC=WO&NR=2014081581A3 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_mFPVNp-LHlIDSt6K1H2sfhnRtaidrE7oP515G03YgSDdcxX_fa910T3tLcnAkB_fxS-4uAHcYE2vCVDVZN1Iha1ks0A7OLDlBzdNTPYkfrLJQOAgNf6i9jPVxDT7WtTBVn9DvqjkialSC-l5U9nrxf4nlVrmVy3vxjkvzJ2_QdqUVOlYqeCK5nTblzGWO5DiI26Qw-qWZim4qtroDu2UgXXbap6NOWZey2HQq3hHsceSXF8dQy_IGHDjrv9casB-snrxxuNK-5Qlwv_vs995Ij6H4XGIHLOI-G_YJ9exRN6LhhDgs4KzfLe-diB26hEfMQRETxHo4ptwukx_IwKekbwf0FG49OnB8Gbc2_ZPE9JVtnkM9g3o-z7NzIDNdEYlhJS0zzjQrFbGa6Kn1KIwWIiIzsy6guY3T5XbyFRyWU7nqJ9mEevH5lV2jLy7ETSXCH0EihiQ |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8NADA9zivNNp-LH1AOlb0VrP9Y-DOn6Yattr3TdnL6Mfg0E6Yar-O-bnpvuaW_hAuEukOR-uSQHcIN3YilVRYmXlTzlpSJJ0Q9ONT5Dy5NzOUvutLpR2A8UZyg9jeVxAz5WvTBsTug3G46IFpWhvVfMX8__k1gmq61c3KbvuDR7sOOeyS3RscDgCWf2e1ZITWpwhoG4jQuiX54qyKqgi1uw3UVQyMDSqF_3pczXg4q9DzshyiurA2gUZRtaxurvtTbs-ssnbySX1rc4hNBxHx3vlXgU1WcS3adR6NDhgFi2PnIjK3gjBvVDOnDrvBPRA5OEETVQxQSxHtJWqNfFDyR2LDLQfesIrm0rNhwetzb508Tkha6fQzyGZjkrixMgU1lIM0XLumpSSFqeJmIm59p9qnQREamFdgqdTZLONrOvoOXEvjfx3OD5HPZqFs9mS3agWX1-FRcYl6v0kqnzB6vAiQ4 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=HIGHLY+LOADED+AMORPHOUS+EFAVIRENZ+COMPOSITION+AND+PROCESS+FOR+PREPARING+THE+SAME&rft.inventor=LESTER%2C+JAMES%2C+DAVID&rft.inventor=DURIG%2C+THOMAS&rft.inventor=RAHMAN%2C+MOHAMMED%2C+ABDUL&rft.inventor=BULL%2C+RANDY&rft.inventor=BI%2C+YUNXIA&rft.date=2014-07-17&rft.externalDBID=A3&rft.externalDocID=WO2014081581A3 |