1,3-DIOXANOMORPHIDES AND 1,3-DIOXANOCODIDES

The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein G, R2-R5, and (a) are defined as set forth in the specification. The invention is also directed to use of compounds of Formula (I) as synthetic intermediates or to t...

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Bibliographic Details
Main Author REISCH, HELGE, A
Format Patent
LanguageEnglish
French
Published 06.03.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein G, R2-R5, and (a) are defined as set forth in the specification. The invention is also directed to use of compounds of Formula (I) as synthetic intermediates or to treat disorders responsive to the modulation of one or more opiopid receptors. Certain compounds of the present invention are especially useful for treating pain. La présente invention concerne des composés de formule (I) et leurs sels, promédicaments et solvates pharmaceutiquement acceptables, G, R2 à R5 et (a) étant définis dans le mémoire descriptif. L'invention concerne également l'utilisation de composés de formule (I) comme intermédiaires de synthèse ou pour traiter des troubles répondant à la modulation d'un ou de plusieurs récepteurs opioïdes. Certains composés selon la présente invention sont particulièrement utiles pour traiter la douleur.
Bibliography:Application Number: WO2013IB01877