PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS

• Main Authors: VIVET, BERTRAND, GANZHORM, AXEL, FILOCHE-ROMME, BRUNO, MUZET, NICOLAS, RONAN, BAPTISTE, MARCINIAK, GILBERT, EL-AHMAD, YOUSSEF, ZERR, VÉRONIQUE
• Format: Patent
• Language: English; French
• Published: 28.05.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n = 0 or 1 and R2 is a methyl group when n = 0 and a hydrogen atom...