GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS IN WOMEN, METHODS OF DETECTION AND USES THEREOF

• Main Authors: ZOTZ, RAINER, BERND, SCHARF, RUEDIGER, SZAFARCZYK, DANIEL, GERHARDT, ANDREA
• Format: Patent
• Language: English; French
• Published: 11.04.2013
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

Methods and kits for identifying a woman having an increased risk of developing venous thrombosis, requiring prophylactic or therapeutic treatment are provided, and methods for identifying an agent useful in prophylactically or therapeutically treating venous thrombosis in women, said methods comprising genotyping the woman with respect to the F9 G32023A (rs440051) polymorphism and/or the F9 5:32164:6/4 polymorphism (rs35599944). L'invention concerne des procédés et des trousses pour l'identification d'une femme présentant un risque accru de développement d'une thrombose veineuse, nécessitant un traitement prophylactique ou thérapeutique, et des procédés d'identification d'un agent utile dans le traitement prophylactique ou thérapeutique d'une thrombose veineuse chez des femmes, lesdits procédés comprenant le génotypage de la femme par rapport au polymorphisme F9 G32023A (rs440051) et/ou au polymorphisme F9 5:32164:6/4 (rs35599944).