METHODS AND COMPOSITIONS FOR DETECTING CANCER BASED ON MIRNA EXPRESSION PROFILES

• Main Authors: WHITNEY, DUNCAN, H, LUO, JUN
• Format: Patent
• Language: English; French
• Published: 07.03.2013
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The disclosure in some aspects provides methods of determining the likelihood that a subject has lung cancer based on the expression of informative miRNAs. In other aspects, the disclosure provides methods for determining a treatment course for a subject based on the expression of informative-miRNAs. The disclosure also provides computer implemented methods for processing genomic information relating to miRNA expression. Related compositions and kits are provided in other aspects of the disclosure. L'invention concerne, dans certains aspects, des procédés de détermination de la probabilité qu'un sujet présente un cancer du poumon sur la base de l'expression de miARN informatifs. Dans d'autres aspects, l'invention concerne des procédés de détermination d'un parcours de traitement pour un sujet sur la base de l'expression de miARN informatifs. L'invention concerne également des procédés informatiques pour le traitement d'informations génomiques associées à l'expression de miARN. L'invention concerne des compositions et trousses associées dans d'autres aspects de l'invention.