METAL BISPHOSPHONATE NANOPARTICLES FOR ANTI-CANCER THERAPY AND IMAGING AND FOR TREATING BONE DISORDERS

• Main Authors: LIU, DEMIN, DELLA ROCCA, JOSEPH, POON, CHRISTOPHER, Y, LIN, WENBIN, KRAMER, STEPHANIE, A
• Format: Patent
• Language: English; French
• Published: 07.11.2013
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone- resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents. L'invention porte sur des nanoparticules de métal-bisphosphonate, ainsi que sur des compositions pharmaceutiques comprenant les nanoparticules de métal-bisphosphonate, sur des procédés de préparation des nanoparticules de métal-bisphosphonate et de matériaux comportant les nanoparticules et sur des procédés d'utilisation des compositions pour traiter un cancer ou des troubles liés aux os (par exemple des maladies liées à la résorption osseuse, l'ostéoporose, la maladie de Paget et les métastases osseuses) et comme agents d'imagerie.