COMPOSITIONS AND METHODS FOR INCREASING PROLIFERATION OF ADULT SALIVARY STEM CELLS

• Main Authors: MOCHLY-ROSEN, DARIA, LE, QUYNH-THU, CHEN, CHE-HONG
• Format: Patent
• Language: English; French
• Published: 01.11.2012
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an individual undergoing radiotherapy for head and neck cancer. La présente invention concerne des procédés d'augmentation de la prolifération de cellules souches salivaires adultes. Les procédés comprennent la mise en contact des cellules souches salivaires adultes in vivo, in vitro ou ex vivo avec un agoniste d'une aldéhyde déshydrogénase (ALDH). L'augmentation de la prolifération des cellules souches salivaires adultes peut être mise en oeuvre pour permettre l'augmentation du nombre de cellules souches salivaires adultes chez un individu soumis à une radiothérapie pour un cancer de la tête et du cou.