PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS
The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as "PPA derivatives"), particularly 1H-pyrrolo[3,2-c]pyridine-6- amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1 - also known as TTK) kinases e...
Saved in:
| Main Authors | , , , , |
|---|---|
| Format | Patent |
| Language | English French |
| Published |
20.09.2012
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as "PPA derivatives"), particularly 1H-pyrrolo[3,2-c]pyridine-6- amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1 - also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular, the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives, and pharmaceutical compositions comprising them. Formula (I)
La présente invention concerne l'utilisation de certains dérivés pyrrolopyridineamino (ci-après rapportés en tant que «dérivés PPA»), en particulier les dérivés 1H-pyrrolo[3,2-c]pyridine-6-amino, pour inhiber la fonction de checkpoint du fuseau des Monofuseaux 1 (Mps1 - aussi connues comme TTK) kinases soit directement soit indirectement via l'interaction avec la Mps kinase elle-même. En particulier, la présente invention concerne des dérivés PPA pour l'utilisation en tant qu'agents thérapeutiques pour le traitement et/ou la prévention de maladies prolifératives, comme le cancer. La présente invention concerne aussi les procédés pour la préparation des dérivés PPA derivatives, et des compositions pharmaceutiques les comprenant. Formule (I) |
|---|---|
| AbstractList | The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as "PPA derivatives"), particularly 1H-pyrrolo[3,2-c]pyridine-6- amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1 - also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular, the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives, and pharmaceutical compositions comprising them. Formula (I)
La présente invention concerne l'utilisation de certains dérivés pyrrolopyridineamino (ci-après rapportés en tant que «dérivés PPA»), en particulier les dérivés 1H-pyrrolo[3,2-c]pyridine-6-amino, pour inhiber la fonction de checkpoint du fuseau des Monofuseaux 1 (Mps1 - aussi connues comme TTK) kinases soit directement soit indirectement via l'interaction avec la Mps kinase elle-même. En particulier, la présente invention concerne des dérivés PPA pour l'utilisation en tant qu'agents thérapeutiques pour le traitement et/ou la prévention de maladies prolifératives, comme le cancer. La présente invention concerne aussi les procédés pour la préparation des dérivés PPA derivatives, et des compositions pharmaceutiques les comprenant. Formule (I) |
| Author | BLAGG, JULIAN BAVETSIAS, VASSILIOS NAUD, SEBASTIEN GASTON ANDRE ATRASH, BUTRUS SHELDRAKE, PETER WILLIAM |
| Author_xml | – fullname: ATRASH, BUTRUS – fullname: NAUD, SEBASTIEN GASTON ANDRE – fullname: SHELDRAKE, PETER WILLIAM – fullname: BLAGG, JULIAN – fullname: BAVETSIAS, VASSILIOS |
| BookMark | eNrjYmDJy89L5WQwDogMCvL38QdSni6efq6Ovp5-_gourkGeYY4hnmGuwQqOwQq-AcGGCp5-Hp5OniH-QcE8DKxpiTnFqbxQmptB2c01xNlDN7UgPz61uCAxOTUvtSQ-3N_IwNDI0MjY3MTU0dCYOFUAhWoqQw |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| DocumentTitleAlternate | DÉRIVÉS PYRROLOPYRIDINEAMINO EN TANT QU'INHIBITEURS DE MPS1 |
| ExternalDocumentID | WO2012123745A1 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_WO2012123745A13 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 15:59:49 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English French |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_WO2012123745A13 |
| Notes | Application Number: WO2012GB50564 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120920&DB=EPODOC&CC=WO&NR=2012123745A1 |
| ParticipantIDs | epo_espacenet_WO2012123745A1 |
| PublicationCentury | 2000 |
| PublicationDate | 20120920 |
| PublicationDateYYYYMMDD | 2012-09-20 |
| PublicationDate_xml | – month: 09 year: 2012 text: 20120920 day: 20 |
| PublicationDecade | 2010 |
| PublicationYear | 2012 |
| RelatedCompanies | BLAGG, JULIAN BAVETSIAS, VASSILIOS NAUD, SEBASTIEN GASTON ANDRE CANCER RESEARCH TECHNOLOGY LIMITED ATRASH, BUTRUS SHELDRAKE, PETER WILLIAM |
| RelatedCompanies_xml | – name: NAUD, SEBASTIEN GASTON ANDRE – name: BAVETSIAS, VASSILIOS – name: CANCER RESEARCH TECHNOLOGY LIMITED – name: ATRASH, BUTRUS – name: BLAGG, JULIAN – name: SHELDRAKE, PETER WILLIAM |
| Score | 2.867733 |
| Snippet | The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as "PPA derivatives"), particularly... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120920&DB=EPODOC&locale=&CC=WO&NR=2012123745A1 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB5KFfWmVbFaJaDkFkyzSdMeiqR50BWTDUmM9VSaZAOCpMVG_PvOhlZ76mlfsC-Ymf1255sFeMgNYg5Jgdik5LqCFooIJ4CBUnBOBHmmHHFBFPaDwfRVf54ZsxZ8brkwTZzQnyY4IkpUjvJeN_p69X-J5TS-levH7AOrlk9eMnbkDToWRFBNlZ3J2A2Zw2zZthG3yUHUtKGSNnXDQqx0IA7SItK-m04EL2W1a1S8UzgMsb-qPoMWrzpwbG__XuvAkb958sbsRvrW50DC9yhiLwwT6tDAtXwaMMlBKJZaCU3dWLJiyQ_jvkSDKZ3QhEXxBdx7bmJPFRx9_rfY-RvbnSq5hHa1rPgVSJzomb7QMsK5qQ8X_azM8GiT88WwUM3cGHWht6-n6_3NN3AiisITQlN70K6_vvktmts6u2t26RcCW35f |
| link.rule.ids | 230,309,786,891,25594,76903 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEL8QNOKbokYUdYlmb0SgG4MHYvZFVmXrsk3EJ8JGl5iYQWTGf99rA8oTT216yfUjuV5_7f2uAA-ZTow-WSA2ybnWQg9FRBBAr7XgnAjyTD7ggijsBz3vVXue6tMKfG65MDJP6I9MjogWlaG9l3K_Xv1fYjkytnL9mH5g0_JplAwddYOOBRG021Yda-iGzGG2atuI29QgkjLcpA1NNxErHRgICiVYmliCl7LadSqjEzgMUV9RnkKFF3Wo2du_1-pw5G-evLG6sb71GZDwPYrYmGFBHRq4pk8DpjgIxSZmQidurJix4odxR6GBRy2asCg-h_uRm9heC3uf_U129sZ2h0ouoFosC34JCidaqs27KeHc0PrzTpqneLTJ-Ly_aBuZPmhAc5-mq_3iO6h5iT-ejWnwcg3HQiSiIrrtJlTLr29-g663TG_liv0CEAWBSQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=PYRROLOPYRIDINEAMINO+DERIVATIVES+AS+MPS1+INHIBITORS&rft.inventor=ATRASH%2C+BUTRUS&rft.inventor=NAUD%2C+SEBASTIEN+GASTON+ANDRE&rft.inventor=SHELDRAKE%2C+PETER+WILLIAM&rft.inventor=BLAGG%2C+JULIAN&rft.inventor=BAVETSIAS%2C+VASSILIOS&rft.date=2012-09-20&rft.externalDBID=A1&rft.externalDocID=WO2012123745A1 |