ANTI-DIABETIC COMPOUNDS

The present invention provides a FGF21 molecule covalently attached to the combining site of an antibody via a linker, wherein the linker is covalently attached to the side chain of a linking residue within FGF21. Various uses of the compounds are provided, including methods to prevent or treat diab...

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Main Authors VIOLAND, BERNARD NORMAN, PALANKI, MOORTHY SITHARAMAIAH SURIYANARAYANA, PARSONS, ERIN, KRISTEN, ISHINO, TETSUYA, DAS, TAPAN, KANTI, HODGE, TAMARA, SHAFER, LEVIN, NANCY, JANE
Format Patent
LanguageEnglish
French
Published 28.06.2012
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Summary:The present invention provides a FGF21 molecule covalently attached to the combining site of an antibody via a linker, wherein the linker is covalently attached to the side chain of a linking residue within FGF21. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions. La présente invention concerne une molécule de FGF21 liée de façon covalente au site de combinaison d'un anticorps via un pont, ledit pont étant lié de façon covalente à la chaîne latérale d'un résidu de liaison au sein de FGF21. La présente invention concerne diverses utilisations des composés, y compris des méthodes de traitement prophylactique ou thérapeutique du diabète ou d'états pathologiques liés au diabète.
Bibliography:Application Number: WO2011IB54874