RNA INTERFERENCE MEDIATED INHIBITION OF MITOGEN-ACTIVATED PROTEIN KINASE 1 (MAPK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

• Main Authors: MA, YONG, BROWN, DUNCAN, SEMYONOV, JENIA, BARTZ, STEVEN
• Format: Patent
• Language: English; French
• Published: 24.05.2012
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMES; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; VINEGAR; WINE

The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of MAPK1 gene expression and/or activity, and/or modulate a MAPK1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against MAPK1 gene expression. La présente invention concerne des composés, des compositions, et des procédés pour l'étude, le diagnostic, et le traitement de traits, maladies et pathologies qui répondent à la modulation de l'expression et/ou de l'activité du gène MAPK1 et/ou modulent une voie d'expression du gène MAPK1. Spécifiquement, l'invention concerne des molécules d'acide nucléique double-brin incluant de petites molécules d'acide nucléique, comme un acide nucléique à courte interférence (siNA), un ARN à courte interférence (siARN), un ARN double-brin (dsARN), un micro-ARN (miARN), et un court ARN en épingle à cheveux (shARN), molécules qui sont capables de médier ou qui médient l'interférence d'ARN (ARNi) contre l'expression du gène MAPK1.