COLON AND PANCREAS CANCER SPECIFIC ANTIGENS AND ANTIBODIES

This invention relates to NPC-1 antigen on the MUC5AC protein and 16C3 antigen on CEACAM5 and CEACAM6 proteins, and 31.1 epitope on the A33 protein are differentially expressed in cancers including, lung cancer, ovarian cancer, pancreas cancer, breast cancer, and colon cancer, and diagnostic and the...

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Main Authors BRISTOL, J., ANDREW, DU, XIULIAN, LUKA, JANOS, WANG, XUE-PING, KANTOR, JUDITH, STAFFORD, LEWIS JOE, SEMENUK, MARK
Format Patent
LanguageEnglish
French
Published 29.12.2011
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This invention relates to NPC-1 antigen on the MUC5AC protein and 16C3 antigen on CEACAM5 and CEACAM6 proteins, and 31.1 epitope on the A33 protein are differentially expressed in cancers including, lung cancer, ovarian cancer, pancreas cancer, breast cancer, and colon cancer, and diagnostic and therapeutic usages. Further, NPC-1, 16C3, and/or 31.1 epitope specific antibodies and diagnostic and therapeutic methods of use. Cette invention concerne un antigène NPC-1 sur la protéine MUC5AC et un antigène 16C3 sur les protéines CEACAM5 et CEACAM6 et un épitope 31.1 sur la protéine A33 qui sont exprimés de façon différentielle dans des cancers, comprenant le cancer du poumon, le cancer ovarien, le cancer du pancréas, le cancer du sein et le cancer du côlon, et des utilisations de diagnostic et thérapeutiques. En outre, l'invention concerne des anticorps spécifiques des épitopes NPC-1, 16C3 et/ou 31.1, et des méthodes de diagnostic et thérapeutiques d'utilisation.
Bibliography:Application Number: WO2011US41502