METHOD OF PREPARING A GRANULATED PHARMACEUTICAL COMPOSITION COMPRISING SIMVASTATIN AND/OR EZETIMIBE
A method of preparing a granulated pharmaceutical composition by wet granulation, which method comprises: (a) suspending one or more pharmaceutically active ingredients comprising statin or ezetimibe or both statin and ezetimibe in a granulating liquid to form a granulating suspension; (b) optionall...
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Format | Patent |
Language | English French |
Published |
29.09.2011
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Abstract | A method of preparing a granulated pharmaceutical composition by wet granulation, which method comprises: (a) suspending one or more pharmaceutically active ingredients comprising statin or ezetimibe or both statin and ezetimibe in a granulating liquid to form a granulating suspension; (b) optionally subjecting the granulating suspension of step (a) to high pressure homogenisation; (c) adding the granulating suspension of step (a) or (b) to a composition comprising one or more pharmaceutically acceptable inactive ingredients; and (d) granulating the mixture of step (c), as well as pharmaceutical compositions obtained by this process.
La présente invention a pour objet un procédé de préparation d'une composition pharmaceutique sous forme de granulés par granulation humide, lequel procédé comprend : (a) la mise en suspension d'un ou plusieurs principes pharmaceutiquement actifs comprenant une statine ou de l'ézétimib ou à la fois une statine et de l'ézétimib dans un liquide de granulation pour former une suspension de granulation ; (b) la soumission éventuelle de la suspension de granulation de l'étape (a) à une homogénéisation à haute pression ; (c) l'addition de la suspension de granulation de l'étape (a) ou (b) à une composition contenant un ou plusieurs composants inactifs pharmaceutiquement acceptables ; et (d) la granulation du mélange de l'étape (c), ainsi que des compositions pharmaceutiques obtenues par ce procédé. |
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AbstractList | A method of preparing a granulated pharmaceutical composition by wet granulation, which method comprises: (a) suspending one or more pharmaceutically active ingredients comprising statin or ezetimibe or both statin and ezetimibe in a granulating liquid to form a granulating suspension; (b) optionally subjecting the granulating suspension of step (a) to high pressure homogenisation; (c) adding the granulating suspension of step (a) or (b) to a composition comprising one or more pharmaceutically acceptable inactive ingredients; and (d) granulating the mixture of step (c), as well as pharmaceutical compositions obtained by this process.
La présente invention a pour objet un procédé de préparation d'une composition pharmaceutique sous forme de granulés par granulation humide, lequel procédé comprend : (a) la mise en suspension d'un ou plusieurs principes pharmaceutiquement actifs comprenant une statine ou de l'ézétimib ou à la fois une statine et de l'ézétimib dans un liquide de granulation pour former une suspension de granulation ; (b) la soumission éventuelle de la suspension de granulation de l'étape (a) à une homogénéisation à haute pression ; (c) l'addition de la suspension de granulation de l'étape (a) ou (b) à une composition contenant un ou plusieurs composants inactifs pharmaceutiquement acceptables ; et (d) la granulation du mélange de l'étape (c), ainsi que des compositions pharmaceutiques obtenues par ce procédé. |
Author | GERMAN, TAMARA VRECER, FRANC BUKOVEC, POLONA |
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DocumentTitleAlternate | PROCÉDÉ DE PRÉPARATION D'UNE COMPOSITION PHARMACEUTIQUE SOUS FORME DE GRANULÉS CONTENANT DE LA SIMVASTATINE ET/OU DE L'ÉZÉTIMIB |
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RelatedCompanies | GERMAN, TAMARA VRECER, FRANC BUKOVEC, POLONA KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO |
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Title | METHOD OF PREPARING A GRANULATED PHARMACEUTICAL COMPOSITION COMPRISING SIMVASTATIN AND/OR EZETIMIBE |
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