PROCESS FOR THE PREPARATION OF GADOBENATE DIMEGLUMINE COMPLEX IN A SOLID FORM

The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly a...

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Main Authors ANELLI, PIER LUCIO, MOROSINI, PIER FRANCESCO, UGGERI, FULVIO, FERRIGATO, AURELIA, FRETTA, ROBERTA, LATTUADA, LUCIANO, CERAGIOLI, SILVIA
Format Patent
LanguageEnglish
French
Published 26.05.2011
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Abstract The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions. La présente invention concerne un procédé de préparation d'un complexe de gadobénate diméglumine sous une forme solide. En particulier, ladite forme solide est avantageusement obtenue par séchage par pulvérisation d'une suspension liquide correspondante à une température et une concentration données. La présente invention est particulièrement avantageuse à l'échelle industrielle étant donné que la forme solide peut être obtenue en utilisant en tant que solvant de l'eau, qui est un solvant non toxique, facile à manipuler et ne requérant fondamentalement pas de précautions sanitaires ou sécuritaires lourdes.
AbstractList The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions. La présente invention concerne un procédé de préparation d'un complexe de gadobénate diméglumine sous une forme solide. En particulier, ladite forme solide est avantageusement obtenue par séchage par pulvérisation d'une suspension liquide correspondante à une température et une concentration données. La présente invention est particulièrement avantageuse à l'échelle industrielle étant donné que la forme solide peut être obtenue en utilisant en tant que solvant de l'eau, qui est un solvant non toxique, facile à manipuler et ne requérant fondamentalement pas de précautions sanitaires ou sécuritaires lourdes.
Author CERAGIOLI, SILVIA
ANELLI, PIER LUCIO
UGGERI, FULVIO
FERRIGATO, AURELIA
MOROSINI, PIER FRANCESCO
FRETTA, ROBERTA
LATTUADA, LUCIANO
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ANELLI, PIER LUCIO
UGGERI, FULVIO
FERRIGATO, AURELIA
MOROSINI, PIER FRANCESCO
FRETTA, ROBERTA
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Snippet The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently...
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title PROCESS FOR THE PREPARATION OF GADOBENATE DIMEGLUMINE COMPLEX IN A SOLID FORM
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