A METHOD FOR THE PREPARATION OF TIZANIDINE HYDROCHLORIDE

The invention deals with a preparation method of salts of 5-chloro-4-(2-imidazolin-2-yl- amino)-2,l,3-benzothiadiazole (tizanidine) of formula I, especially tizanidine hydrochloride, comprising preparation of a salt of tizanidine of formula I and a carboxylic acid as an intermediate, from which, aft...

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Bibliographic Details
Main Authors KVAPIL, LUBOMIR, HRADIL, PAVEL, GREPL, MARTIN, NOVOTNY, JAN
Format Patent
LanguageEnglish
French
Published 12.08.2010
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Summary:The invention deals with a preparation method of salts of 5-chloro-4-(2-imidazolin-2-yl- amino)-2,l,3-benzothiadiazole (tizanidine) of formula I, especially tizanidine hydrochloride, comprising preparation of a salt of tizanidine of formula I and a carboxylic acid as an intermediate, from which, after acidification with hydrogen chloride, tizanidine hydrochloride is obtained in a high yield and purity. Cette invention concerne un procédé de préparation de sels de 5-chloro-4-(2-imidazolin-2-yl-amino)-2,l,3-benzothiadiazole (tizanidine) de formule I, notamment du chlorhydrate de tizanidine, ledit procédé comprenant la préparation d'un sel de tizanidine de formule I et d'un acide carboxylique à titre d'intermédiaire, à partir desquels est obtenu, après acidification avec un chlorure d'hydrogène, le chlorhydrate de tizanidine à un rendement et une pureté élevés.
Bibliography:Application Number: WO2009CZ00158