A METHOD FOR THE PREPARATION OF TIZANIDINE HYDROCHLORIDE
The invention deals with a preparation method of salts of 5-chloro-4-(2-imidazolin-2-yl- amino)-2,l,3-benzothiadiazole (tizanidine) of formula I, especially tizanidine hydrochloride, comprising preparation of a salt of tizanidine of formula I and a carboxylic acid as an intermediate, from which, aft...
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Main Authors | , , , |
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Format | Patent |
Language | English French |
Published |
12.08.2010
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Subjects | |
Online Access | Get full text |
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Summary: | The invention deals with a preparation method of salts of 5-chloro-4-(2-imidazolin-2-yl- amino)-2,l,3-benzothiadiazole (tizanidine) of formula I, especially tizanidine hydrochloride, comprising preparation of a salt of tizanidine of formula I and a carboxylic acid as an intermediate, from which, after acidification with hydrogen chloride, tizanidine hydrochloride is obtained in a high yield and purity.
Cette invention concerne un procédé de préparation de sels de 5-chloro-4-(2-imidazolin-2-yl-amino)-2,l,3-benzothiadiazole (tizanidine) de formule I, notamment du chlorhydrate de tizanidine, ledit procédé comprenant la préparation d'un sel de tizanidine de formule I et d'un acide carboxylique à titre d'intermédiaire, à partir desquels est obtenu, après acidification avec un chlorure d'hydrogène, le chlorhydrate de tizanidine à un rendement et une pureté élevés. |
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Bibliography: | Application Number: WO2009CZ00158 |