Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease

The invention relates to novel organic compounds of formula (I), and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the t...

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Main Authors RAO, CHANG, JI, NAN, MA, FUPENG, ELLIOTT, JASON MATTHEW, LIU, DONGLEI, MEREDITH, ERIK, MIRANDA, KARL, POWERS, JAMES J, ARTMAN III, GERALD DAVID, MAINOLFI, NELLO
Format Patent
LanguageEnglish
French
Published 17.06.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to novel organic compounds of formula (I), and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases. L'invention se réfère à de nouveaux composés organiques représentés par la formule (I) et à leur utilisation pour traiter des êtres humains ou des animaux, ainsi qu'à des compositions pharmaceutiques comprenant un composé représenté par la formule I et à l'utilisation d'un tel composé pour élaborer des compositions pharmaceutiques destinées à traiter des maladies dépendant de protéines kinases, en particulier des maladies prolifératives, par exemple pour traiter des tumeurs et des maladies oculaires néovasculaires.
Bibliography:Application Number: WO2009EP66540