COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY

Compounds of formula (I): wherein R1, L2, R2, L3, R3, L4 and R4 are as defined herein, upregulate endogenous utrophin in predictive screens, and thus, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dystrophy, Becker muscular dystrophy, and cachexia. L'invent...

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Main Authors LECCI, CRISTINA, SCHROER, FRANK, POIGNANT, SEVERINE, DANIELLE, WILSON, FRANCIS, MA, SHUCONG, VAN WELL, RENATE, MARIA, WREN, STEPHEN, WYNNE, GRAHAM, MICHAEL
Format Patent
LanguageEnglish
French
Published 29.04.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Compounds of formula (I): wherein R1, L2, R2, L3, R3, L4 and R4 are as defined herein, upregulate endogenous utrophin in predictive screens, and thus, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dystrophy, Becker muscular dystrophy, and cachexia. L'invention porte sur des composés de formule (I) : dans laquelle R1, L2, R2, L3, R3, L4 et R4 sont tels que définis dans la description. Les composés régulent de façon positive l'utrophine endogène dans des dépistages prédictifs, et sont ainsi utiles pour le traitement ou la prophylaxie d'états tels qu'une dystrophie musculaire de Duchenne, une dystrophie musculaire de Becker et une cachexie.
AbstractList Compounds of formula (I): wherein R1, L2, R2, L3, R3, L4 and R4 are as defined herein, upregulate endogenous utrophin in predictive screens, and thus, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dystrophy, Becker muscular dystrophy, and cachexia. L'invention porte sur des composés de formule (I) : dans laquelle R1, L2, R2, L3, R3, L4 et R4 sont tels que définis dans la description. Les composés régulent de façon positive l'utrophine endogène dans des dépistages prédictifs, et sont ainsi utiles pour le traitement ou la prophylaxie d'états tels qu'une dystrophie musculaire de Duchenne, une dystrophie musculaire de Becker et une cachexie.
Author WYNNE, GRAHAM, MICHAEL
WREN, STEPHEN
LECCI, CRISTINA
VAN WELL, RENATE, MARIA
SCHROER, FRANK
MA, SHUCONG
POIGNANT, SEVERINE, DANIELLE
WILSON, FRANCIS
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– fullname: WREN, STEPHEN
– fullname: WYNNE, GRAHAM, MICHAEL
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DocumentTitleAlternate COMPOSÉS POUR LE TRAITEMENT D'UNE DYSTROPHIE MUSCULAIRE DE DUCHENNE
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WREN, STEPHEN
LECCI, CRISTINA
VAN WELL, RENATE, MARIA
SCHROER, FRANK
BIOMARIN IGA LIMITED
MA, SHUCONG
POIGNANT, SEVERINE, DANIELLE
WILSON, FRANCIS
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Snippet Compounds of formula (I): wherein R1, L2, R2, L3, R3, L4 and R4 are as defined herein, upregulate endogenous utrophin in predictive screens, and thus, are...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY
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