PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS

The invention provides novel pyrimidine derivatives of formula I and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin- li...

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Bibliographic Details
Main Authors MARSILJE III, THOMAS H, LEE, CHRISTIAN CHO-HUA, LU, WENSHUO, HE, XIAOHUI, YANG, KUNYONG, CHEN, BEI, JIANG, SONGCHUN
Format Patent
LanguageEnglish
French
Published 01.04.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention provides novel pyrimidine derivatives of formula I and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin- like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK). La présente invention concerne de nouveaux dérivés de pyrimidine et des compositions pharmaceutiques de ceux-ci, et des procédés d'utilisation de tels composés. Par exemple, les dérivés de pyrimidine de l'invention peuvent être utilisés pour traiter, améliorer ou prévenir une pathologie qui est influencée par l'inhibition du facteur de croissance insulinomimétique (IGF-1R) ou de la kinase de lymphome anaplasique (ALK).
Bibliography:Application Number: WO2009US48428