INTEGRATED-MODEL MUSCULOSKELETAL THERAPIES
Anatomical structures such as the musculoskeletal structure of a knee or hip joint, are modeled using a predictive cause-and-effect mathematical model wherein parameters and interactions associated with biological tissues are examined. The model extends over nested small scale parameters (e.g., gene...
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Format | Patent |
Language | English French |
Published |
13.08.2009
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Abstract | Anatomical structures such as the musculoskeletal structure of a knee or hip joint, are modeled using a predictive cause-and-effect mathematical model wherein parameters and interactions associated with biological tissues are examined. The model extends over nested small scale parameters (e.g., genetic or cellular) up to macro scale parameters, e.g., body force and motion. The parameter values are populated for a subject or group, and the model is operated iteratively while subjecting the parameters to one or more influences, to project changes over a span of time that encompasses adaptive changes in tissues and also aging and wear.
Selon l'invention, des structures anatomiques, telles que la structure musculosquelettique d'une articulation de genou ou de hanche, sont modélisées à l'aide d'un modèle mathématique cause-effet prédictif, dans lequel des paramètres et des interactions associés à des tissus biologiques sont examinés. Le modèle s'étend sur des paramètres de petite échelle imbriqués (par exemple, génétiques ou cellulaires) jusqu'à des paramètres à l'échelle macroscopique, par exemple, force et mouvement des corps. Les valeurs de paramètres sont chargées pour un sujet ou groupe, et le modèle est mis en oevre de manière itérative, tout en soumettant les paramètres à une ou plusieurs influences, pour projeter des changements sur une étendue de temps qui englobe des changements adaptatifs dans des tissus et également le vieillissement et l'usure. |
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AbstractList | Anatomical structures such as the musculoskeletal structure of a knee or hip joint, are modeled using a predictive cause-and-effect mathematical model wherein parameters and interactions associated with biological tissues are examined. The model extends over nested small scale parameters (e.g., genetic or cellular) up to macro scale parameters, e.g., body force and motion. The parameter values are populated for a subject or group, and the model is operated iteratively while subjecting the parameters to one or more influences, to project changes over a span of time that encompasses adaptive changes in tissues and also aging and wear.
Selon l'invention, des structures anatomiques, telles que la structure musculosquelettique d'une articulation de genou ou de hanche, sont modélisées à l'aide d'un modèle mathématique cause-effet prédictif, dans lequel des paramètres et des interactions associés à des tissus biologiques sont examinés. Le modèle s'étend sur des paramètres de petite échelle imbriqués (par exemple, génétiques ou cellulaires) jusqu'à des paramètres à l'échelle macroscopique, par exemple, force et mouvement des corps. Les valeurs de paramètres sont chargées pour un sujet ou groupe, et le modèle est mis en oevre de manière itérative, tout en soumettant les paramètres à une ou plusieurs influences, pour projeter des changements sur une étendue de temps qui englobe des changements adaptatifs dans des tissus et également le vieillissement et l'usure. |
Author | NASH, MARTYN PETER MALCOLM, DUANE TEARAITOA KINGWELL HUNTER, PETER JOHN NIELSEN, POUL MICHAEL FONSS MITHRARATNE, PREMAKUMAR SHIM, BO KYUNG ANDERSON, IAIN ALEXANDER GILMOUR, ROBERT FARRER |
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DocumentTitleAlternate | THÉRAPIES MUSCULOSQUELETTIQUES À MODÈLE INTÉGRÉ |
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Title | INTEGRATED-MODEL MUSCULOSKELETAL THERAPIES |
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