COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

The invention provides compounds of formula (I) and salts thereof wherein R1, R2, R3, R4 and X are as defined in the description. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction o...

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Main Authors HARRISON, STEPHEN, WARD, SIMON, E, THEWLIS, KEVIN, MICHAEL, HUGHES, OWEN, RHYS, NEESOM, JAMES, KENNETH, CHAN, WAI, NGOR
Format Patent
LanguageEnglish
French
Published 30.04.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention provides compounds of formula (I) and salts thereof wherein R1, R2, R3, R4 and X are as defined in the description. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed. L'invention concerne des composés de formule (I) et leurs sels, dans laquelle R1, R2, R3, R4 et X sont tels que définis dans la description. L'invention concerne également leurs procédés de préparation, leurs compositions pharmaceutiques et leurs utilisations en tant que médicament, par exemple pour le traitement d'une maladie ou d'un trouble induit par une réduction ou un déséquilibre du fonctionnement du récepteur de glutamate, par exemple la schizophrénie ou une déficience cognitive.
AbstractList The invention provides compounds of formula (I) and salts thereof wherein R1, R2, R3, R4 and X are as defined in the description. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed. L'invention concerne des composés de formule (I) et leurs sels, dans laquelle R1, R2, R3, R4 et X sont tels que définis dans la description. L'invention concerne également leurs procédés de préparation, leurs compositions pharmaceutiques et leurs utilisations en tant que médicament, par exemple pour le traitement d'une maladie ou d'un trouble induit par une réduction ou un déséquilibre du fonctionnement du récepteur de glutamate, par exemple la schizophrénie ou une déficience cognitive.
Author NEESOM, JAMES, KENNETH
CHAN, WAI, NGOR
WARD, SIMON, E
HARRISON, STEPHEN
HUGHES, OWEN, RHYS
THEWLIS, KEVIN, MICHAEL
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DocumentTitleAlternate COMPOSÉS QUI POTENTIALISENT LE RÉCEPTEUR AMPA ET LEURS UTILISATIONS EN MÉDECINE
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CHAN, WAI, NGOR
WARD, SIMON, E
HARRISON, STEPHEN
HUGHES, OWEN, RHYS
THEWLIS, KEVIN, MICHAEL
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– name: NEESOM, JAMES, KENNETH
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Snippet The invention provides compounds of formula (I) and salts thereof wherein R1, R2, R3, R4 and X are as defined in the description. Processes for preparation,...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE
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