LIQUID CRYSTAL EMULSION-TYPE PHARMACEUTICAL COMPOSITION CONTAINING CYCLOSPORINE, AND METHOD OF TREATING CUTANEOUS DISEASE THEREWITH
A dermal external pharmaceutical composition that excels in feeling at application or after application and that by enhancing of the transdermal absorption of cyclosporine, exerts medicinal benefits at low concentration. There is provided a liquid crystal emulsion-type pharmaceutical composition com...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English French Japanese |
| Published |
19.03.2009
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| Subjects | |
| Online Access | Get full text |
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| Abstract | A dermal external pharmaceutical composition that excels in feeling at application or after application and that by enhancing of the transdermal absorption of cyclosporine, exerts medicinal benefits at low concentration. There is provided a liquid crystal emulsion-type pharmaceutical composition comprising cyclosporine, a hydrophilic nonionic surfactant, a lipophilic nonionic surfactant, an oil, a fatty acid that is insoluble in the oil at room temperature, a solid higher alcohol that is insoluble in the oil at room temperature and a water-soluble polyhydric alcohol that is immiscible with the oil at room temperature, and a method of treating cutaneous diseases with the use of the pharmaceutical composition.
L'invention porte sur une composition pharmaceutique externe dermique qui présente une excellente caractéristique en termes de sensation à l'application ou après l'application et qui, par l'amélioration de l'absorption transdermique de la cyclosporine, exerce des bénéfices médicaux à une concentration faible. L'invention propose une composition pharmaceutique de type émulsion de cristaux liquides comportant de la cyclosporine, un agent tensioactif non ionique hydrophile, un agent tensioactif non ionique lipophile, un contenu huileux, un acide gras insoluble dans le contenu huileux à la température ambiante, un alcool supérieur solide insoluble dans le contenu huileux à la température ambiante et un polyol soluble dans l'eau immiscible avec le contenu huileux à la température ambiante, et propose un procédé de traitement de maladies de la peau à l'aide de la composition pharmaceutique. |
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| AbstractList | A dermal external pharmaceutical composition that excels in feeling at application or after application and that by enhancing of the transdermal absorption of cyclosporine, exerts medicinal benefits at low concentration. There is provided a liquid crystal emulsion-type pharmaceutical composition comprising cyclosporine, a hydrophilic nonionic surfactant, a lipophilic nonionic surfactant, an oil, a fatty acid that is insoluble in the oil at room temperature, a solid higher alcohol that is insoluble in the oil at room temperature and a water-soluble polyhydric alcohol that is immiscible with the oil at room temperature, and a method of treating cutaneous diseases with the use of the pharmaceutical composition.
L'invention porte sur une composition pharmaceutique externe dermique qui présente une excellente caractéristique en termes de sensation à l'application ou après l'application et qui, par l'amélioration de l'absorption transdermique de la cyclosporine, exerce des bénéfices médicaux à une concentration faible. L'invention propose une composition pharmaceutique de type émulsion de cristaux liquides comportant de la cyclosporine, un agent tensioactif non ionique hydrophile, un agent tensioactif non ionique lipophile, un contenu huileux, un acide gras insoluble dans le contenu huileux à la température ambiante, un alcool supérieur solide insoluble dans le contenu huileux à la température ambiante et un polyol soluble dans l'eau immiscible avec le contenu huileux à la température ambiante, et propose un procédé de traitement de maladies de la peau à l'aide de la composition pharmaceutique. |
| Author | AKAMATSU, RYO FUJII, MASAHIRO SAKAGUCHI, TOMOKI HORISAWA, EIJIRO |
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| DocumentTitleAlternate | COMPOSITION PHARMACEUTIQUE DE TYPE ÉMULSION DE CRISTAUX LIQUIDES CONTENANT DE LA CYCLOSPORINE ET PROCÉDÉ DE TRAITEMENT D'UNE MALADIE DE LA PEAU PAR CELLE-CI |
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| RelatedCompanies | AKAMATSU, RYO FUJII, MASAHIRO MARUHO CO., LTD SAKAGUCHI, TOMOKI HORISAWA, EIJIRO |
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| Title | LIQUID CRYSTAL EMULSION-TYPE PHARMACEUTICAL COMPOSITION CONTAINING CYCLOSPORINE, AND METHOD OF TREATING CUTANEOUS DISEASE THEREWITH |
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